Non-coding RNAs in disease: from mechanisms to therapeutics

K Nemeth, R Bayraktar, M Ferracin… - Nature Reviews Genetics, 2024 - nature.com
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …

Long non-coding RNAs in the regulation of gene expression: physiology and disease

JCR Fernandes, SM Acuña, JI Aoki, LM Floeter-Winter… - Non-coding RNA, 2019 - mdpi.com
The identification of RNAs that are not translated into proteins was an important
breakthrough, defining the diversity of molecules involved in eukaryotic regulation of gene …

Obesity II: establishing causal links between chemical exposures and obesity

JJ Heindel, S Howard, K Agay-Shay, JP Arrebola… - Biochemical …, 2022 - Elsevier
Obesity is a multifactorial disease with both genetic and environmental components. The
prevailing view is that obesity results from an imbalance between energy intake and …

LncRNADisease 2.0: an updated database of long non-coding RNA-associated diseases

Z Bao, Z Yang, Z Huang, Y Zhou, Q Cui… - Nucleic acids …, 2019 - academic.oup.com
Mounting evidence suggested that dysfunction of long non-coding RNAs (lncRNAs) is
involved in a wide variety of diseases. A knowledgebase with systematic collection and …

LNCipedia 5: towards a reference set of human long non-coding RNAs

PJ Volders, J Anckaert, K Verheggen… - Nucleic acids …, 2019 - academic.oup.com
While long non-coding RNA (lncRNA) research in the past has primarily focused on the
discovery of novel genes, today it has shifted towards functional annotation of this large …

Towards a complete map of the human long non-coding RNA transcriptome

B Uszczynska-Ratajczak, J Lagarde… - Nature Reviews …, 2018 - nature.com
Gene maps, or annotations, enable us to navigate the functional landscape of our genome.
They are a resource upon which virtually all studies depend, from single-gene to genome …

MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) as new tools for cancer therapy: first steps from bench to bedside

M Ratti, A Lampis, M Ghidini, M Salati, MB Mirchev… - Targeted …, 2020 - Springer
Non-coding RNAs represent a significant proportion of the human genome. After having
been considered as 'junk'for a long time, non-coding RNAs are now well established as …

MicroRNAs and complex diseases: from experimental results to computational models

X Chen, D Xie, Q Zhao, ZH You - Briefings in bioinformatics, 2019 - academic.oup.com
Plenty of microRNAs (miRNAs) were discovered at a rapid pace in plants, green algae,
viruses and animals. As one of the most important components in the cell, miRNAs play a …

NONCODEV5: a comprehensive annotation database for long non-coding RNAs

SS Fang, LL Zhang, JC Guo, YW Niu, Y Wu… - Nucleic acids …, 2018 - academic.oup.com
Abstract NONCODE (http://www. bioinfo. org/noncode/) is a systematic database that is
dedicated to presenting the most complete collection and annotation of non-coding RNAs …

Roles, functions, and mechanisms of long non-coding RNAs in cancer

Y Fang, MJ Fullwood - Genomics, Proteomics and …, 2016 - academic.oup.com
Long non-coding RNAs (lncRNAs) play important roles in cancer. They are involved in
chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through …