Quantitative MRI provides biophysical measures of the microstructural integrity of the CNS,
which can be compared across CNS regions, patients, and centres. In patients with multiple …

Cognitive impairment (CI) is common and debilitating in patients with multiple sclerosis.
However, little is known about how different disease courses affect CI, impeding prognosis …

Background: There is limited and inconsistent information on the clinical determinants of
cognitive impairment (CI) in multiple sclerosis (MS). Objective: The aim of this study was to …

The exact pathogenesis of multiple sclerosis (MS) is incompletely understood. Although auto-
immune responses have an important role in the development of hallmark focal …

Background Multiple sclerosis (MS) is a complex chronic inflammatory and degenerative
disorder of the central nervous system. Accelerated brain volume loss, or also termed …

Objectives Recent studies supported coagulation involvement in multiple sclerosis, an
inflammatory-demyelinating and degenerative disease of the central nervous system. The …

Background While gray matter (GM) perfusion abnormalities have been evidenced in
multiple sclerosis (MS) patients, the relationships with disability still remain unclear …

Background: The cognitive performance in multiple sclerosis (MS) patients declines with
aging, longer disease duration, and possibly cardiovascular comorbidities. Objectives: We …

Introduction: Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and
neurodegenerative disease of the central nervous system. Over the last two decades, more …

There is copious evidence of abnormalities in resting-state functional network connectivity
states, grey and white matter pathology and impaired cerebral perfusion in patients afforded …