Background: Type 2 diabetes mellitus (T2DM) has been associated with an increased risk of
developing several common cancers, but it is unclear whether this association is causal. We …

Obesity, exceptionally prevalent in the USA, promotes the incidence and progression of
numerous cancer types including breast cancer. Complex, interacting metabolic and …

Physical activity has been associated with lower risks of breast and colorectal cancer in
epidemiological studies; however, it is unknown if these associations are causal or …

Obesity and diabetes have both been associated with an increased risk of cancer. In the
face of increasing obesity and diabetes rates worldwide, this is a worrying trend for cancer …

Purpose The purpose of the present study was to systematically review the complex
associations between energy balance-related factors and breast cancer risk, for which …

Genetic studies have examined body-shape measures adjusted for body mass index (BMI),
while allometric indices are additionally adjusted for height. We performed the first genome …

Accumulating evidence indicates that obesity with its associated metabolic dysregulation,
including hyperinsulinemia and aberrant circadian rhythms, increases the risk for a variety of …

Background We aimed to map and describe the current state of Mendelian randomization
(MR) literature on cancer risk and to identify associations supported by robust evidence …

Background Observational studies have investigated the association of risk factors with
breast cancer prognosis. However, the results have been conflicting and it has been …

Background Evidence for the impact of body size and composition on cancer risk is limited.
This mendelian randomisation (MR) study investigates evidence supporting causal …