The mammary gland is one of the most regenerative organs in the body, with the majority of
development occurring postnatally and in the adult mammal. Formation of the ductal tree is …

Our understanding of the molecular events underpinning the development of mammalian
organ systems has been increasing rapidly in recent years. With the advent of new and …

Apical–basal polarity is essential for the formation and function of epithelial tissues, whereas
loss of polarity is a hallmark of tumours. Studies in Drosophila have identified conserved …

Animal models of cancer have been instrumental in advancing our understanding of the
biology of tumor initiation and progression, in studying gene function and in performing …

Adult mammary stem cells (MaSCs) drive postnatal organogenesis and remodeling in the
mammary gland, and their longevity and potential have important implications for breast …

Cell polarity is a fundamental property of most animal cells and is critical during
development and for most cell and tissue functions. Epithelial cells are organized into apical …

The mammary gland is a unique tissue and the defining feature of the class Mammalia. It is a
late-evolving epidermal appendage that has the primary function of providing nutrition for …

The tumor suppressor LKB1 is an essential serine/threonine kinase, which regulates various
cellular processes such as cell metabolism, cell proliferation, cell polarity, and cell migration …

The mammary gland is a dynamic organ that undergoes extensive morphogenesis during
the different stages of embryonic development, puberty, estrus, pregnancy, lactation and …

The Par‐3/Baz family of polarity determinants is highly conserved across metazoans and
includes C. elegans PAR‐3, Drosophila Bazooka (Baz), human Par‐3 (PARD3), and human …