The influence of gut microbiota on neurogenesis: evidence and hopes

F Sarubbo, V Cavallucci, G Pani - Cells, 2022 - mdpi.com
Adult neurogenesis (ie, the life-long generation of new neurons from undifferentiated
neuronal precursors in the adult brain) may contribute to brain repair after damage, and …

[HTML][HTML] The gut microbiome and adult hippocampal neurogenesis: A new focal point for epilepsy?

S Dohm-Hansen, F Donoso, PJ Lucassen… - Neurobiology of …, 2022 - Elsevier
Temporal lobe epilepsy (TLE) is a neurological disorder affecting millions of people
worldwide and currently represents the most common form of focal epilepsy. Thus, the …

TNF-α: A serological marker for evaluating the severity of hippocampal sclerosis in medial temporal lobe epilepsy?

B Wang, Q Li, H Wang, X Du, Q Lai, X Li… - Journal of Clinical …, 2024 - Elsevier
Objective By analysing the difference in TNF-α levels in the peripheral blood of patients with
medial temporal lobe epilepsy (mTLE) with or without hippocampal sclerosis and the …

Cuproptosis-related genes signature and validation of differential expression and the potential targeting drugs in temporal lobe epilepsy

X Yang, X Zhang, K Shen, Z Wang, G Liu… - Frontiers in …, 2023 - frontiersin.org
Introduction: Temporal lobe epilepsy (TLE) is the most common subtype of epilepsy in adults
and is characterized by neuronal loss, gliosis, and sprouting mossy fibers in the …

Promoting endogenous neurogenesis as a treatment for Alzheimer's disease

Q Zhang, J Liu, L Chen, M Zhang - Molecular Neurobiology, 2023 - Springer
Alzheimer's disease (AD) is the most universal neurodegenerative disorder characterized by
memory loss and cognitive impairment. AD is biologically defined by production and …

The Role of Histone Deacetylases in NLRP3 Inflammasomesmediated Epilepsy

X Kuang, S Chen, Q Ye - Current Molecular Medicine, 2024 - ingentaconnect.com
Epilepsy is one of the most common brain disorders that not only causes death worldwide,
but also affects the daily lives of patients. Previous studies have revealed that inflammation …

Connexin 43 Promotes Neurogenesis via Regulating Aquaporin-4 after Cerebral Ischemia

H Chu, J Dong, Y Tang, C Huang, Q Guo - Neurotoxicity Research, 2023 - Springer
We aimed to test the effects of connexin43 (Cx43) on ischemic neurogenesis and examined
whether it was dependent on aquaporin-4 (AQP4). We detected the expression of Cx43 and …

[HTML][HTML] Expression and correlation of the NOD-like receptor family, pyrin domain-containing 3 inflammasome and the silent information regulator 1 in patients with …

Q Li, Z Qu, L Jia, W Wang - Epilepsy Research, 2024 - Elsevier
Background The NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammatory
pathway is implicated in the development of epilepsy and can be suppressed by the …

Kainic acid induced hyperexcitability in thalamic reticular nucleus that initiates an inflammatory response through the HMGB1/TLR4 pathway

D Li, X Zhang, R Liu, M Long, S Zhou, J Lin, L Zhang - NeuroToxicology, 2023 - Elsevier
Objective To explore the relationship between the proinflammatory factor high‐mobility
group box 1 (HMGB1) and glutamatergic alpha-amino-3-hydroxy-5-methyl-4 …

[HTML][HTML] A high-density 3-dimensional culture model of human glioblastoma for rapid screening of therapeutic resistance

JMC Brown, M Zaben, C Ormonde, F Sharouf… - Biochemical …, 2023 - Elsevier
Glioblastoma is among the most lethal cancers, with no known cure. A multitude of
therapeutics are being developed or in clinical trials, but currently there are no ways to …