Despite efforts to develop new antibiotics, antibacterial resistance still develops too fast for
drug discovery to keep pace. Often, resistance against a new drug develops even before it …

Since the advent of penicillin, humans have known about and explored the phenomenon of
bacterial inhibition via antibiotics. However, with changes in the global environment and the …

d‐cycloserine (DCS) is an antibiotic that is currently used in second‐line treatment of
tuberculosis. DCS is a structural analogue of d‐alanine, and targets two enzymes involved …

All antibiotics that have been successfully employed for decades as monotherapeutics in the
treatment of bacterial infections rely on mechanisms of bacterial growth inhibition which are …

D-cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan
biosynthesis enzymes: alanine racemase and D-alanine: D-alanine ligase. By a …

Enzymes catalysing the stereo‐chemical inter‐conversion of amino acids are known as
amino acid racemases. In bacteria, these enzymes are fundamental to synthesize the D‐A la …

Based on the mode of action of antibacterial drugs currently used, targets can be defined as
distinct cellular constituents such as enzymes, enzyme substrates, RNA, DNA, and …

Amyloid fibril formation by proteins leads to variety of degenerative disorders called
amyloidosis. While these disorders are topic of extensive research, effective treatments are …

Actinobacteria is a group of diverse bacteria. Most species in this class of bacteria are
filamentous aerobes found in soil, including the genus Streptomyces perhaps best known for …

The Actinobacteria phylum is one of the oldest bacterial phyla that have a significant role in
medicine and biotechnology. There are a lot of genera in this phylum that are causing …