[HTML][HTML] Applications of supramolecular anion recognition

N Busschaert, C Caltagirone, W Van Rossom… - Chemical …, 2015 - ACS Publications
The study of the complexation of anions, from its beginnings in the late 1960s and 1970s,(1-
3) has moved on from being an area solely of academic interest to a fundamental pillar of …

Recent advances in urea-and thiourea-containing compounds: focus on innovative approaches in medicinal chemistry and organic synthesis

R Ronchetti, G Moroni, A Carotti, A Gioiello… - RSC medicinal …, 2021 - pubs.rsc.org
Urea and thiourea represent privileged structures in medicinal chemistry. Indeed, these
moieties constitute a common framework of a variety of drugs and bioactive compounds …

Anion receptor chemistry: highlights from 2011 and 2012

PA Gale, N Busschaert, CJE Haynes… - Chemical Society …, 2014 - pubs.rsc.org
This review covers advances in anion complexation in the years 2011 and 2012. The review
covers both organic and inorganic systems and also highlights the applications to which …

Small‐molecule lipid‐bilayer anion transporters for biological applications

N Busschaert, PA Gale - Angewandte Chemie International …, 2013 - Wiley Online Library
The development of small‐molecule lipid‐bilayer anion transporters for potential future use
in channel replacement therapy for the treatment of diseases caused by dysregulation of …

Chloride-mediated apoptosis-inducing activity of bis (sulfonamide) anionophores

T Saha, MS Hossain, D Saha, M Lahiri… - Journal of the …, 2016 - ACS Publications
Transmembrane anion transport modality is enjoying a renewed interest because of recent
advances toward anticancer therapy. Here we show bis (sulfonamides) as efficient receptors …

Biological applications of synthetic anion transporters

N Akhtar, O Biswas, D Manna - Chemical Communications, 2020 - pubs.rsc.org
The use of synthetic ion transporters for alteration of the concentration of ions across cell
membranes has drawn attention from scientists over the last two decades. This ion transport …

Towards predictable transmembrane transport: QSAR analysis of anion binding and transport

N Busschaert, SJ Bradberry, M Wenzel… - Chemical …, 2013 - pubs.rsc.org
The transport of anions across biological membranes by small molecules is a growing
research field due to the potential therapeutic benefits of these compounds. However, little is …

A model for a solvent-free synthetic organic research laboratory: click-mechanosynthesis and structural characterization of thioureas without bulk solvents

V Štrukil, MD Igrc, L Fábián, M Eckert-Maksić… - Green chemistry, 2012 - pubs.rsc.org
The mechanochemical click coupling of isothiocyanates and amines has been used as a
model reaction to demonstrate that the concept of a solvent-free research laboratory, which …

Acylthioureas as anion transporters: the effect of intramolecular hydrogen bonding

CJE Haynes, N Busschaert, IL Kirby… - Organic & …, 2014 - pubs.rsc.org
Small molecule synthetic anion transporters may have potential application as therapeutic
agents for the treatment of diseases including cystic fibrosis and cancer. Understanding the …

Lipophilic balance–a new design principle for transmembrane anion carriers

H Valkenier, CJE Haynes, J Herniman, PA Gale… - Chemical …, 2014 - pubs.rsc.org
Despite extensive interest in transmembrane anion carriers (anionophores), the factors that
govern activity are still only partly understood. Herein we report a study which identifies a …