Most complex trait-associated variants are located in non-coding regulatory regions of the
genome, where they have been shown to disrupt transcription factor (TF)-DNA binding …

Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …

Targeted proteomics technique has emerged as a powerful protein quantification tool in
systems biology, biomedical research, and increasing for clinical applications. The most …

Transcription factors (TFs) bind to specific DNA motifs to regulate the expression of target
genes. To reach their binding sites, TFs diffuse in 3D and perform local motions such as 1D …

Enhancers regulate gene expression through the binding of sequence-specific transcription
factors (TFs) to cognate motifs. Various features influence TF binding and enhancer function …

Dynamic cellular processes such as differentiation are driven by changes in the abundances
of transcription factors (TFs). However, despite years of studies, our knowledge about the …

Many cellular functions rely on DNA-binding proteins finding and associating to specific sites
in the genome. Yet the mechanisms underlying the target search remain poorly understood …

The development of novel therapies against neurodegenerative disorders requires the
ability to detect their early, presymptomatic manifestations in order to enable treatment …

Specific recognition of cis-regulatory regions is essential for correct gene regulation in
response to developmental and environmental signals. Such DNA sequences are …

The enormous diversity of proteoforms produces tremendous complexity within cellular
proteomes, facilitates intricate networks of molecular interactions, and constitutes a …