Over the past decade, melanoma has led the field in new cancer treatments, with impressive
gains in on-treatment survival but more modest improvements in overall survival. Melanoma …

Wound healing is one of the most complex processes in the human body. It involves the
spatial and temporal synchronization of a variety of cell types with distinct roles in the …

Malignant melanoma is notorious for its inter-and intratumour heterogeneity, based on
transcriptionally distinct melanoma cell phenotypes. It is thought that these distinct …

All transcription factors are equal, but some are more equal than others. In the 25 yr since
the gene encoding the microphthalmia-associated transcription factor (MITF) was first …

Melanocytes are melanin-producing cells found in skin, hair follicles, eyes, inner ear, bones,
heart and brain of humans. They arise from pluripotent neural crest cells and differentiate in …

Empirical and anecdotal evidence has associated stress with accelerated hair greying
(formation of unpigmented hairs),, but so far there has been little scientific validation of this …

The skin protects mammals from insults, infection and dehydration and enables
thermoregulation and sensory perception. Various skin-resident cells carry out these diverse …

Functional modeling of many adult epithelia is limited by the difficulty in maintaining relevant
stem cell populations in culture. Here, we show that dual inhibition of SMAD signaling …

Certain transcription factors have vital roles in lineage development, including specification
of cell types and control of differentiation. Microphthalmia-associated transcription factor …

Vitiligo is an autoimmune skin disease characterized by the targeted destruction of
melanocytes by T cells. Cytokine signaling between keratinocytes and T cells results in …