Therapeutic significance of β-glucuronidase activity and its inhibitors: A review

P Awolade, N Cele, N Kerru, L Gummidi… - European journal of …, 2020 - Elsevier
The emergence of disease and dearth of effective pharmacological agents on most
therapeutic fronts, constitutes a major threat to global public health and man's existence …

Novel 1, 2, 3-triazole compounds: Synthesis, In vitro xanthine oxidase inhibitory activity, and molecular docking studies

A Tan - Journal of Molecular Structure, 2020 - Elsevier
Abstract In this study, novel 1, 2, 3-triazole compounds containing carbasugar frameworks (5
and 6) were synthesized by the copper-catalyzed azide-alkyne cycloaddition reactions and …

The dual role of fucosidases: tool or target

C Jiménez-Pérez, F Guzmán-Rodríguez… - Biologia, 2023 - Springer
Regular intake of fucosylated oligosaccharides has been associated with several benefits
for human health, particularly for new-borns. Since these biologically active molecules can …

Synthesis of triazole bridged N-glycosides of pyrazolo [1, 5-a] pyrimidinones as anticancer agents and their in silico docking studies

G Tiwari, VK Mishra, P Kumari, A Khanna, S Sharma… - RSC …, 2024 - pubs.rsc.org
In the pursuit of novel therapeutic agents, we present a comprehensive study on the design,
synthesis, and evaluation of a diverse library of triazole bridged N-glycosides of pyrazolo [1 …

Molecular Design, synthesis and anticancer activity of novel Pyrazolo [3, 4-b] pyridine-based glycohybrid molecules

N Verma, G Tiwari, A Khanna, VK Mishra, Y Yadav… - Bioorganic …, 2025 - Elsevier
Molecular hybridization is an emerging strategy in medicinal chemistry for designing new
bioactive molecules that link pharmacophores covalently and shows synergistic enhanced …

Glycohybrid molecules in medicinal chemistry: Present status and future prospective

P Kumari, C Narayana, G Tiwari, R Sagar - Carbohydrates in Drug …, 2020 - Elsevier
Hybrid molecules combine two distinct biologically relevant molecules that act at different
biological targets with new mechanism are becoming molecules for interest among …

Total Syntheses of Kirkamide and N‐acetyl ent‐Conduramine B‐1

C Narayana, A Khanna, P Kumari… - Asian Journal of Organic …, 2021 - Wiley Online Library
The second total synthesis of recently isolated new C7N aminocyclitol, kirkamide, has been
developed. The enantiopure epoxide derived from N‐acetylglucosamine in few steps was …

Approaches to the Total Synthesis of Conduramines: A Review

H Bharathkumar, JS Krishna, B Surender… - SynOpen, 2022 - thieme-connect.com
This review reports on the total synthesis of conduramines, which are formally derived from
conduritols, mainly containing a trihydroxy aminocyclohexene core. Analysis of the different …

Efficient stereoselective synthesis of 5a-carba-α-L-mannopyranose starting from naturally abundant (−)-shikimic acid

XL Zhu, XR Liang, YQ Luo, L Wang… - Synthetic …, 2021 - Taylor & Francis
In this article, an efficient and practical stereoselective synthesis of 5a-carba-α-L-
mannopyranose from naturally abundant (−)-shikimic acid is discussed. 5a-Carba-α-L …

Replacement of oxocarbenium ions by allylic cations in both enzymatic and spontaneous reactions of glycosides

PM Danby - 2021 - open.library.ubc.ca
Oxocarbenium ions play a pivotal role in the chemistry and biochemistry of glycosides. In
this thesis I prepared carbocyclic glycoside analogs that can generate allylic cations in the …