Verification of ferroptosis and pyroptosis and identification of PTGS2 as the hub gene in human coronary artery atherosclerosis

Y Zhou, H Zhou, L Hua, C Hou, Q Jia, J Chen… - Free Radical Biology …, 2021 - Elsevier
Ferroptosis and pyroptosis have not been fully studied in atherosclerosis. We aimed to
investigate the expression of ferroptosis-related and pyroptosis-related proteins in human …

Deletion of BACH1 attenuates atherosclerosis by reducing endothelial inflammation

M Jia, Q Li, J Guo, W Shi, L Zhu, Y Huang, Y Li… - Circulation …, 2022 - Am Heart Assoc
Background: The transcription factor BACH1 (BTB and CNC homology 1) suppressed
endothelial cells (ECs) proliferation and migration and impaired angiogenesis in the …

The Role of Nrf2/sMAF Signalling in Retina Ageing and Retinal Diseases

J Zhang, T Zhang, S Zeng, X Zhang, F Zhou, MC Gillies… - Biomedicines, 2023 - mdpi.com
Age-related diseases, such as Parkinson's disease, Alzheimer's disease, cardiovascular
diseases, cancers, and age-related macular disease, have become increasingly prominent …

The potential of integrating human and mouse discovery platforms to advance our understanding of cardiometabolic diseases

AW Jurrjens, MM Seldin, C Giles, PJ Meikle, BG Drew… - Elife, 2023 - elifesciences.org
Cardiometabolic diseases encompass a range of interrelated conditions that arise from
underlying metabolic perturbations precipitated by genetic, environmental, and lifestyle …

[HTML][HTML] PROTAC technology as a novel tool to identify the target of lathyrane diterpenoids

Y Wu, Y Yang, W Wang, D Sun, J Liang… - Acta Pharmaceutica …, 2022 - ncbi.nlm.nih.gov
Proteolysis Targeting Chimera (PROTAC) is an emerging approach to selectively degrading
target proteins by utilizing endogenous proteasome 1. Since PROTACs can degrade target …

[HTML][HTML] Biotinylation of an acetylenic tricyclic bis (cyanoenone) lowers its potency as an NRF2 activator while creating a novel activity against BACH1

R Moreno, L Casares, M Higgins, KX Ali… - Free Radical Biology …, 2022 - Elsevier
The transcription factor BACH1 regulates the expression of a variety of genes including
genes involved in oxidative stress responses, inflammation, cell motility, cancer cell invasion …

[HTML][HTML] The synthetic triterpenoids CDDO-TFEA and CDDO-Me, but not CDDO, promote nuclear exclusion of BACH1 impairing its activity

L Casares, R Moreno, KX Ali, M Higgins, SD Naidu… - Redox Biology, 2022 - Elsevier
The transcription factor BACH1 is a potential therapeutic target for a variety of chronic
conditions linked to oxidative stress and inflammation, as well as cancer metastasis …

Synthesis of Lathyrol PROTACs and evaluation of their anti-inflammatory activities

W Wang, Y Liu, L Xiong, D Sun, H Wang… - Journal of Natural …, 2023 - ACS Publications
Lathyrol is a core scaffold structure of many lathyrane diterpenoids with potent anti-
inflammatory activity isolated from Euphorbia lathyrism. It was chosen as a framework to …

Vascular tissue specific miRNA profiles reveal novel correlations with risk factors in coronary artery disease

KD Neiburga, B Vilne, S Bauer, D Bongiovanni… - Biomolecules, 2021 - mdpi.com
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide.
Non-coding RNAs have already been linked to CVD development and progression. While …

Development of hydrogen sulfide donors for anti-atherosclerosis therapeutics research: Challenges and future priorities

YW Yang, NH Deng, KJ Tian, LS Liu, Z Wang… - Frontiers in …, 2022 - frontiersin.org
Hydrogen sulfide (H2S), a gas transmitter found in eukaryotic organisms, plays an essential
role in several physiological processes. H2S is one of the three primary biological gas …