M Jia, Q Li, J Guo, W Shi, L Zhu, Y Huang, Y Li… - Circulation …, 2022 - Am Heart Assoc
Background: The transcription factor BACH1 (BTB and CNC homology 1) suppressed endothelial cells (ECs) proliferation and migration and impaired angiogenesis in the …
Age-related diseases, such as Parkinson's disease, Alzheimer's disease, cardiovascular diseases, cancers, and age-related macular disease, have become increasingly prominent …
Cardiometabolic diseases encompass a range of interrelated conditions that arise from underlying metabolic perturbations precipitated by genetic, environmental, and lifestyle …
Y Wu, Y Yang, W Wang, D Sun, J Liang… - Acta Pharmaceutica …, 2022 - ncbi.nlm.nih.gov
Proteolysis Targeting Chimera (PROTAC) is an emerging approach to selectively degrading target proteins by utilizing endogenous proteasome 1. Since PROTACs can degrade target …
R Moreno, L Casares, M Higgins, KX Ali… - Free Radical Biology …, 2022 - Elsevier
The transcription factor BACH1 regulates the expression of a variety of genes including genes involved in oxidative stress responses, inflammation, cell motility, cancer cell invasion …
L Casares, R Moreno, KX Ali, M Higgins, SD Naidu… - Redox Biology, 2022 - Elsevier
The transcription factor BACH1 is a potential therapeutic target for a variety of chronic conditions linked to oxidative stress and inflammation, as well as cancer metastasis …
W Wang, Y Liu, L Xiong, D Sun, H Wang… - Journal of Natural …, 2023 - ACS Publications
Lathyrol is a core scaffold structure of many lathyrane diterpenoids with potent anti- inflammatory activity isolated from Euphorbia lathyrism. It was chosen as a framework to …
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Non-coding RNAs have already been linked to CVD development and progression. While …
YW Yang, NH Deng, KJ Tian, LS Liu, Z Wang… - Frontiers in …, 2022 - frontiersin.org
Hydrogen sulfide (H2S), a gas transmitter found in eukaryotic organisms, plays an essential role in several physiological processes. H2S is one of the three primary biological gas …