Applications of powder X-ray diffraction in small molecule pharmaceuticals: achievements and aspirations
NK Thakral, RL Zanon, RC Kelly, S Thakral - Journal of pharmaceutical …, 2018 - Elsevier
Since the discovery of X-ray diffraction and its potential to elucidate crystal symmetry,
powder X-ray diffraction has found diverse applications in the field of pharmaceutical …
powder X-ray diffraction has found diverse applications in the field of pharmaceutical …
An examination of water vapor sorption by multicomponent crystalline and amorphous solids and its effects on their solid-state properties
A Newman, G Zografi - Journal of pharmaceutical sciences, 2019 - Elsevier
This commentary critically evaluated the unique effects of water vapor sorption by
multicomponent solid forms of active pharmaceutical ingredients (APIs), and its effects on …
multicomponent solid forms of active pharmaceutical ingredients (APIs), and its effects on …
Pharmaceutical cocrystals: formulation approaches to develop robust drug products
Phase transformation of an active pharmaceutical ingredient in the solid state can influence
the physicochemical properties and consequently drug product performance. The neat …
the physicochemical properties and consequently drug product performance. The neat …
Detecting and quantifying microscale chemical reactions in pharmaceutical tablets by stimulated Raman scattering microscopy
It has been estimated that approximately 50% of all marketed drug molecules are
manufactured and administered in the form of salts, often with the goal of improving …
manufactured and administered in the form of salts, often with the goal of improving …
Kinetic barriers to disproportionation of salts of weakly basic drugs
Disproportionation is a major issue in formulations containing salts of weakly basic drugs.
Despite considerable interest in risk assessment approaches for disproportionation, the …
Despite considerable interest in risk assessment approaches for disproportionation, the …
Effect of excipient properties, water activity, and water content on the disproportionation of a pharmaceutical salt
Excipients are crucial components of most pharmaceutical formulations. In the case of a
solid oral dosage formulation containing the salt form of a weakly ionizable drug, excipient …
solid oral dosage formulation containing the salt form of a weakly ionizable drug, excipient …
The Effect of In-Situ-Generated Moisture on Disproportionation of Pharmaceutical Salt
AO Weldeab, JD McElderry, Y Lin - Molecular Pharmaceutics, 2022 - ACS Publications
Pharmaceutical salts are ubiquitously present in the market given their benefits in optimizing
the critical properties of an active pharmaceutical ingredient (API). Achieving these benefits …
the critical properties of an active pharmaceutical ingredient (API). Achieving these benefits …
Effect of Physicochemical Properties on the Basic Drug-Acid-Polymer Interactions and Miscibility in PVA Based Orodispersible Films
J Liu, Y Zhang, C Liu, L Fang - The AAPS Journal, 2024 - Springer
Salts of weakly basic drugs can partially dissociate in formulations, to give basic drugs and
counter acids. The aim of the present study was to clarify the effect of physicochemical …
counter acids. The aim of the present study was to clarify the effect of physicochemical …
Development of new multicomponent crystals of the antifungal drug tioconazole and the assessment of their biopharmaceutical attributes
Tioconazole is commonly used as a broad-spectrum topical antifungal. The poor aqueous
solubility and toxicity are two major concerns for its use in oral dosage forms. We have tried …
solubility and toxicity are two major concerns for its use in oral dosage forms. We have tried …
Professor Lynne S. Taylor: Scientist, educator, and adventurer
This special edition of the Journal of Pharmaceutical Sciences is dedicated to Professor
Lynne S. Taylor (Retter Distinguished Professor of Pharmacy, Department of Industrial and …
Lynne S. Taylor (Retter Distinguished Professor of Pharmacy, Department of Industrial and …