ABSTRACT Introduction: Chagas disease affects 8–10 million people worldwide, mainly in
Latin America. The current therapy for Chagas disease is limited to nifurtimox and …

Chagas disease and African sleeping sickness are trypanosomal infections that represent
important public health problems in Latin America and Africa, respectively. The restriction of …

A novel series of thiosemicarbazone and aminoacyl-thiazolidones derivatives were
synthesized. Their structure suggests that these compounds could have anti-Trypanosoma …

It has been over a century since Carlos Chagas discovered the Trypanosoma cruzi (T. cruzi)
as the causative agent of Chagas disease (CD), a neglected tropical disease with several …

Fused diaza-heterocycles constitute the core structure of numerous bioactive natural
products and effective therapeutic drugs. Among them, phthalazines have been recognized …

In this work we reported the synthesis and the trypanocidal profile of new 1, 3, 4-thiadiazole-
2-arylhydrazone derivatives of nitroimidazole series (4) or phenyl series (5), designed by …

To date treatment of trypanosomiasis urgently requires new effective and non-toxic drugs.
The article covers some of the achievements in the search for new antitrypanosomal agents; …

Chagas disease or American Trypanosomiasis, a parasitic infection typically spread by
triatomine bugs, affects millions of people throughout Latin America. Current chemotherapy …

Nitrocompounds are bioactive molecules used as antibacterial, antiparasitic and antitumoral
agents. In the past of years, these molecules have been broadly studied in several fields …

Significance: Millions of people are infected with trypanosomatids and new therapeutic
approaches are needed. Trypanosomatids possess one mitochondrion per cell and its study …