Tankyrases are multifunctional poly (adenosine diphosphate-ribose) polymerases that
regulate diverse biological processes including telomere maintenance and cellular …

Aberrant activation of the Wnt pathway is emerging as a frequent event during prostate
cancer that can facilitate tumor formation, progression, and therapeutic resistance. Recent …

Background Aberrant WNT/β-catenin signaling drives carcinogenesis. Tankyrases poly
(ADP-ribosyl) ate and destabilize AXINs, β-catenin repressors. Tankyrase inhibitors block …

Among the post-translational modifications of proteins, ADP-ribosylation has been studied
for over fifty years, and a large set of functions, including DNA repair, transcription, and cell …

WNT/β-catenin signaling is aberrantly activated in colorectal cancer (CRC) mainly by loss-of-
function mutations in adenomatous polyposis coli (APC) and is involved in tumor …

The catalytic enzymes tankyrase 1 and 2 (TNKS1/2) alter protein turnover by poly-ADP-
ribosylating target proteins, which earmark them for degradation by the ubiquitin …

The integration and interpretation of multi-omics data play a crucial role in systems biology
for prioritizing vital molecular targets and deciphering core signaling pathways of complex …

Wnt-11 es una proteína que se encuentra altamente expresada en el cáncer de próstata
metastático, donde favorece la diferenciación neuroendocrina, la supervivencia y la …