The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

The basic vertebrate body plan of the zebrafish embryo is established in the first 10 hours of
development. This period is characterized by the formation of the anterior-posterior and …

In a large-scale screen, we isolated mutants displaying a specific visible phenotype in
embryos or early larvae of the zebrafish, Danio rerio. Males were mutagenized with …

Zebrafish embryos and larvae have stage-specific patterns of motility or locomotion. Two
embryonic structures accomplish this behavior: the central nervous system (CNS) and …

We describe the isolation of zebrafish Fgf8 and its expression during gastrulation,
somitogenesis, fin bud and early brain development. By demonstrating genetic linkage and …

The most noticeable morphological feature of the cerebellum is its folded appearance,
whereby fissures separate its anterior-posterior extent into lobules. Each lobule is …

In a screen for early developmental mutants of the zebrafish, we have identified mutations
specifically affecting the internal organs. We identified 53 mutations affecting the …

For the past few years there has been an exponential increase in the use of animal models
to confirm the pathogenicity of candidate disease-causing genetic variants found in patients …

The modulatory aminergic neurotransmitters are involved in practically all important
physiological systems in the brain, and many of them are also involved in human central …

In vertebrate development, the body plan is determined by primordial morphogen gradients
that suffuse the embryo. Retinoic acid (RA) is an important morphogen involved in patterning …