Role of inflammatory chemokines in hypertension

TP Mikolajczyk, P Szczepaniak, F Vidler… - Pharmacology & …, 2021 - Elsevier
Hypertension is associated with immune cells activation and their migration into the kidney,
vasculature, heart and brain. These inflammatory mechanisms are critical for blood pressure …

Immune and inflammatory mechanisms in hypertension

TJ Guzik, R Nosalski, P Maffia… - Nature Reviews …, 2024 - nature.com
Hypertension is a global health problem, with> 1.3 billion individuals with high blood
pressure worldwide. In this Review, we present an inflammatory paradigm for hypertension …

White blood cells and blood pressure: a Mendelian randomization study

M Siedlinski, E Jozefczuk, X Xu, A Teumer… - Circulation, 2020 - Am Heart Assoc
Background: High blood pressure (BP) is a risk factor for cardiovascular morbidity and
mortality. While BP is regulated by the function of kidney, vasculature, and sympathetic …

[HTML][HTML] Emerging role of the inflammasome and pyroptosis in hypertension

C De Miguel, P Pelegrín, A Baroja-Mazo… - International Journal of …, 2021 - mdpi.com
Inflammasomes are components of the innate immune response that have recently emerged
as crucial controllers of tissue homeostasis. In particular, the nucleotide-binding domain …

Inflammation in salt-sensitive hypertension and renal damage

X Lu, SD Crowley - Current hypertension reports, 2018 - Springer
Abstract Purpose of Review Low-grade inflammation drives elevations in blood pressure
(BP) and consequent target organ damage in diverse experimental models of hypertension …

Peripheral immune cell composition is altered in women before and after a hypertension diagnosis

JK Kresovich, Z Xu, KM O'Brien, CG Parks… - …, 2023 - Am Heart Assoc
Background: The development and consequences of hypertension involve multiple
biological systems that may include changes in immune profiles. Whether hypertension is …

Gut-immune-kidney axis: influence of dietary protein in salt-sensitive hypertension

DL Mattson, JH Dasinger, JM Abais-Battad - Hypertension, 2022 - Am Heart Assoc
Humans with salt-sensitive hypertension demonstrate increased morbidity, increased
mortality, and renal end-organ damage when compared with normotensive subjects or those …

Dietary influences on the Dahl SS rat gut microbiota and its effects on salt‐sensitive hypertension and renal damage

JM Abais‐Battad, FL Saravia, H Lund… - Acta …, 2021 - Wiley Online Library
Aim Our previous studies have demonstrated the importance of dietary factors in the
determination of hypertension in Dahl salt‐sensitive (SS) rats. Since the gut microbiota has …

Salt-sensitive increase in macrophages in the kidneys of Dahl SS rats

DJ Fehrenbach, JM Abais-Battad… - American Journal …, 2019 - journals.physiology.org
Studies of Dahl salt-sensitive (SS) rats have shown that renal CD3+ T cells and ED-1+
macrophages are involved in the development of salt-sensitive hypertension and renal …

Systemic immune-inflammation index (SII) may be an effective indicator in predicting the left ventricular hypertrophy for patients diagnosed with hypertension

O Karayiğit, SG Nurkoç, MC Çelik - Journal of human hypertension, 2023 - nature.com
The development of left ventricular hypertrophy (LVH) induced by hypertension is
considered a poor prognosis for patients. Similarly, high values of the systemic immune …