microRNAs in action: biogenesis, function and regulation

R Shang, S Lee, G Senavirathne, EC Lai - Nature Reviews Genetics, 2023 - nature.com
Ever since microRNAs (miRNAs) were first recognized as an extensive gene family> 20
years ago, a broad community of researchers was drawn to investigate the universe of small …

A Compilation of the Diverse miRNA Functions in Caenorhabditis elegans and Drosophila melanogaster Development

DC Quesnelle, WG Bendena, ID Chin-Sang - International Journal of …, 2023 - mdpi.com
MicroRNAs are critical regulators of post-transcriptional gene expression in a wide range of
taxa, including invertebrates, mammals, and plants. Since their discovery in the nematode …

[HTML][HTML] A new miRNA-Modified coxsackievirus B3 inhibits triple negative breast cancer growth with improved safety profile in immunocompetent mice

A Bahreyni, H Liu, Y Mohamud, YC Xue, J Zhang… - Cancer Letters, 2022 - Elsevier
Abstract Coxsackievirus B3 (CVB3) displays great oncolytic activity against various cancer
cells. Previously, we demonstrated that adding targeting sequences (TS) of miR-145/143 …

Germline stem cell integrity and quiescence are controlled by an AMPK-dependent neuronal trafficking pathway

C Wong, P Kadekar, E Jurczak, R Roy - PLoS Genetics, 2023 - journals.plos.org
During periods of energetic stress, Caenorhabditis elegans can execute a developmentally
quiescent stage called “dauer”, during which all germline stem cells undergo a G2 cell cycle …

[HTML][HTML] An ancient pan-cnidarian microRNA regulates stinging capsule biogenesis in Nematostella vectensis

A Fridrich, M Salinas-Saaverda, I Kozlolvski, JM Surm… - Cell Reports, 2023 - cell.com
An ancient evolutionary innovation of a novel cell type, the stinging cell (cnidocyte),
appeared> 600 million years ago in the phylum Cnidaria (sea anemones, corals, hydroids …

A lineage-resolved cartography of microRNA promoter activity in C. elegans empowers multidimensional developmental analysis

W Xu, J Liu, H Qi, R Si, Z Zhao, Z Tao, Y Bai… - Nature …, 2024 - nature.com
Elucidating the expression of microRNAs in developing single cells is critical for functional
discovery. Here, we construct scCAMERA (single-cell cartography of microRNA expression …

The TRIM-NHL RNA-binding protein Brain Tumor coordinately regulates expression of the glycolytic pathway and vacuolar ATPase complex

RP Connacher, RT Roden, KL Huang… - Nucleic acids …, 2024 - academic.oup.com
The essential Drosophila RNA-binding protein Brain Tumor (Brat) represses specific genes
to control embryogenesis and differentiation of stem cells. In the brain, Brat functions as a …

MicroRNA-mediated gene regulation and the resilience of multicellular animals

V Ambros - Postępy Biochemii, 2024 - postepybiochemii.ptbioch.edu.pl
MicroRNAs are small RNAs that enable parts of the genome to regulate the other parts of the
genome by RNA:: RNA complementarity. Genes that encode microRNAs function as trans …

Nonreceptor tyrosine kinase ABL1 regulates lysosomal acidification by phosphorylating the ATP6V1B2 subunit of the vacuolar-type H+-ATPase

C Song, Q Dong, Y Yao, Y Cui, C Zhang, L Lin, L Zhu… - Autophagy, 2025 - Taylor & Francis
The vacuolar-type H+-ATPase (V-ATPase) is a proton pump responsible for controlling the
intracellular and extracellular pH of cells. Its activity and assembly are tightly controlled by …

Differential gene expression and microRNA profile in corpora allata-corpora cardiaca of Aedes aegypti mosquitoes with weak juvenile hormone signalling

Z Qi, K Etebari, M Nouzova, FG Noriega, S Asgari - BMC genomics, 2024 - Springer
The corpora allata-corpora cardiaca (CA-CC) is an endocrine gland complex that regulates
mosquito development and reproduction through the synthesis of juvenile hormone (JH) …