Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

AMP-activated protein kinase (AMPK) is a critical regulator of cellular metabolism and plays
an important role in diabetes, cancer, and vascular disease. In the heart, AMPK activation is …

AMP-activated protein kinase (AMPK) plays a key role in integrating metabolic pathways in
response to energy demand. We identified a mutation in the γ1 subunit (γ1 D316A) that …

The FOXO3 and FOXM1 forkhead box transcription factors, functioning downstream of the
essential PI3K-Akt, Ras-ERK and JNK/p38MAPK signalling cascades, are crucial for cell …

Heart failure is one of the leading causes of death and disability worldwide. Left ventricle
remodeling, fibrosis, and ischemia/reperfusion injury all contribute to the deterioration of …

Cellular energy homeostasis is a fundamental process that governs the overall health of the
cell and is paramount to cell survival. Central to this is the control of ATP generation and …

Fibrosis is a general term encompassing a plethora of pathologies that span all systems and
is marked by increased deposition of collagen. Injury of variable etiology gives rise to …

Medical implants often induce foreign body reaction (FBR) from the host immune system,
which may cause implant failure. Spermidine is a natural polyamine with various important …

As a muscular pump that contracts incessantly throughout life, the heart must constantly
generate cellular energy to support contractile function and fuel ionic pumps to maintain …

We investigated whether treatment of mice with established pressure overload-induced
heart failure (HF) with the naturally occurring polyphenol resveratrol could improve …