Automation and data-driven design of polymer therapeutics
Polymers are uniquely suited for drug delivery and biomaterial applications due to tunable
structural parameters such as length, composition, architecture, and valency. To facilitate …
structural parameters such as length, composition, architecture, and valency. To facilitate …
Advances in polymer design for enhancing oral drug solubility and delivery
Synthetic polymers have enabled amorphous solid dispersions (ASDs) to emerge as an oral
delivery strategy for overcoming poor drug solubility in aqueous environments. Modern ASD …
delivery strategy for overcoming poor drug solubility in aqueous environments. Modern ASD …
Controlling complex coacervation via random polyelectrolyte sequences
The utilization of chemical sequence control in polymeric materials is key to enabling
material design on par with biomacromolecular systems. One important avenue for scalable …
material design on par with biomacromolecular systems. One important avenue for scalable …
The role of polymers in oral bioavailability enhancement; a review
One of the most important obstacles to successful oral drug delivery is the poor solubility of
many drugs in aqueous media. This problem is of intense scientific and practical interest …
many drugs in aqueous media. This problem is of intense scientific and practical interest …
Reversible addition-fragmentation chain-transfer polymerization: Fundamentals and use in practice
EV Chernikova, EV Sivtsov - Polymer Science, Series B, 2017 - Springer
Modern approaches to the synthesis of tailor-made macromolecules by radical
polymerization proceeding through the reversible addition-fragmentation chain-transfer …
polymerization proceeding through the reversible addition-fragmentation chain-transfer …
Sequence Design of Random Heteropolymers as Protein Mimics
Random heteropolymers (RHPs) have been computationally designed and experimentally
shown to recapitulate protein-like phase behavior and function. However, unlike proteins …
shown to recapitulate protein-like phase behavior and function. However, unlike proteins …
PET-RAFT and SAXS: high throughput tools to study compactness and flexibility of single-chain polymer nanoparticles
From protein science, it is well understood that ordered folding and 3D structure mainly arise
from balanced and noncovalent polar and nonpolar interactions, such as hydrogen bonding …
from balanced and noncovalent polar and nonpolar interactions, such as hydrogen bonding …
Mapping Composition Evolution through Synthesis, Purification, and Depolymerization of Random Heteropolymers
Random heteropolymers (RHPs) consisting of three or more comonomers have been
routinely used to synthesize functional materials. While increasing the monomer variety …
routinely used to synthesize functional materials. While increasing the monomer variety …
High-throughput excipient discovery enables oral delivery of poorly soluble pharmaceuticals
Polymeric excipients are crucial ingredients in modern pills, increasing the therapeutic
bioavailability, safety, stability, and accessibility of lifesaving products to combat diseases in …
bioavailability, safety, stability, and accessibility of lifesaving products to combat diseases in …
Hydrogen bonding principle-based molecular design of a polymer excipient and impacts on hydrophobic drug properties: molecular simulation and experiment
S Zhang, T Wang, J Xue, H Xu, S Wu - Biomacromolecules, 2023 - ACS Publications
Although some commercial excipients for improving the solubility of highly crystalline drugs
are widely used, they still cannot cover all types of hydrophobic drugs. In this regard, with …
are widely used, they still cannot cover all types of hydrophobic drugs. In this regard, with …