Calcium/calmodulin-dependent protein kinase II (CaMKII) is upregulated in diabetes and
significantly contributes to cardiac remodeling with increased risk of cardiac arrhythmias …

Calcium ions (Ca2+) play a major role in the cardiac excitation-contraction coupling.
Intracellular Ca2+ concentration increases during systole and falls in diastole thereby …

Human induced pluripotent stem cell (hiPSC) cardiomyocytes (CMs) show less negative
resting membrane potential (RMP), which is attributed to small inward rectifier currents (I …

Based on recent findings, an increased late sodium current (INa, late) plays an important
pathophysiological role in cardiac diseases, including rhythm disorders. The article first …

The heart pumps blood against the mechanical afterload from arterial resistance, and
increased afterload may alter cardiac electrophysiology and contribute to life-threatening …

Background Structural and electrophysiological remodeling characterize heart failure (HF)
enhancing arrhythmias. PKD1 (protein kinase D1) is upregulated in HF and mediates …

Background and Objectives: Enhanced beat-to-beat variability of ventricular repolarization
(BVR) has been linked to arrhythmias and sudden cardiac death. Recent experimental …

Background: Heart failure (HF) is characterized by electrophysiological remodeling resulting
in increased risk of cardiac arrhythmias. Previous reports suggest that elevated inward ionic …

In cardiac patients, life‐threatening tachyarrhythmia is often precipitated by abnormal
changes in ventricular repolarization and refractoriness. Repolarization abnormalities …

The profiles of ion currents during the cardiac action potential can be visualized by the
action potential voltage clamp technique. To obtain multiple ion current data from the same …