Cerebral ischemic injury is a leading cause of death and long-term disability throughout the
world. Peroxisome proliferator-activated receptor gamma (PPAR-ɣ) is a ligand-activated …

Sickle cell disease (SCD) is a hereditary hematological disease with high morbidity and
mortality rates worldwide. Despite being monogenic, SCD patients display a plethora of …

Nitro-fatty acids (NO2-FAs) are unsaturated fatty acid nitration products that exhibit anti-
inflammatory actions in experimental mouse models of autoimmune and allergic diseases …

Tissue fibrosis occurs in response to dysregulated metabolism, pro-inflammatory signaling
and tissue repair reactions. For example, lungs exposed to environmental toxins, cancer …

Oxygenated lipids, called “oxylipins,” serve a variety of important signaling roles within the
cell. Oxylipins have been linked to inflammation and vascular function, and blood patterns …

Significance: Neutrophils are crucial components of the innate immune system that combat
invading pathogens and maintain homeostasis. Nitric oxide (NO•) exerts regulatory …

Several types of exposures can cause acute or chronic inflammatory reactions in the lungs
often leading to asthma, pulmonary fibrosis, chronic obstructive pulmonary disease (COPD) …

Objective: Asthma is an inflammatory airway disease affecting most of the population in the
world. The current medication for asthma relieves airway inflammation but it has serious …

Nitro-fatty acids (NFAs) are endogenous lipid mediators capable of post-translational
modifications of selected regulatory proteins. Here, we investigated the anti-cancerous …

The peroxisome proliferator-activated receptor γ (PPARγ) is a key transcription factor,
operating at the intercept of metabolic control and immunomodulation. It is ubiquitously …