[HTML][HTML] A quantitative view on multivalent nanomedicine targeting

L Woythe, NB Tito, L Albertazzi - Advanced drug delivery reviews, 2021 - Elsevier
Although the concept of selective delivery has been postulated over 100 years ago, no
targeted nanomedicine has been clinically approved so far. Nanoparticles modified with …

Circulating tumour cells: a broad perspective

V Akpe, TH Kim, CL Brown… - Journal of the Royal …, 2020 - royalsocietypublishing.org
Circulating tumour cells (CTCs) have recently been identified as valuable biomarkers for
diagnostic and prognostic evaluations, as well for monitoring therapeutic responses to …

A single-molecule view at nanoparticle targeting selectivity: Correlating ligand functionality and cell receptor density

L Woythe, P Madhikar, N Feiner-Gracia, C Storm… - ACS …, 2022 - ACS Publications
Antibody-functionalized nanoparticles (NPs) are commonly used to increase the targeting
selectivity toward cells of interest. At a molecular level, the number of functional antibodies …

3D-printed smartphone-based point of care tool for fluorescence-and magnetophoresis-based cytometry

S Knowlton, A Joshi, P Syrrist, AF Coskun, S Tasoglu - Lab on a Chip, 2017 - pubs.rsc.org
In developing countries, there are often limited resources available to provide important
medical diagnostics, which severely limits our ability to diagnose conditions and administer …

Past, present, and future of affinity-based cell separation technologies

K Bacon, A Lavoie, BM Rao, M Daniele, S Menegatti - Acta biomaterialia, 2020 - Elsevier
Progress in cell purification technology is critical to increase the availability of viable cells for
therapeutic, diagnostic, and research applications. A variety of techniques are now available …

The use of microfluidic technology for cancer applications and liquid biopsy

A Kulasinghe, H Wu, C Punyadeera, ME Warkiani - Micromachines, 2018 - mdpi.com
There is growing awareness for the need of early diagnostic tools to aid in point-of-care
testing in cancer. Tumor biopsy remains the conventional means in which to sample a tumor …

[HTML][HTML] Placental apoptosis in recurrent miscarriage

TA Atia - The Kaohsiung Journal of Medical Sciences, 2017 - Elsevier
Apoptosis is an interactive and dynamic biological process involved in all phases of
embryogenesis. We aimed to study the effect of placental apoptosis on recurrent miscarriage …

Comparison of eosin and fluorescein conjugates for the photoinitiation of cell-compatible polymer coatings

JL Lilly, A Gottipati, CF Cahall, M Agoub, BJ Berron - PloS one, 2018 - journals.plos.org
Targeted photopolymerization is the basis for multiple diagnostic and cell encapsulation
technologies. While eosin is used in conjunction with tertiary amines as a water-soluble …

Therapeutic considerations of PARP in stem cell biology: Relevance in cancer and beyond

M Zeniou, L Nguekeu-Zebaze, F Dantzer - Biochemical Pharmacology, 2019 - Elsevier
Cancer stem cells (CSCs) are of fundamental importance in tumor progression because of
their tumor-initiating properties, their resistance to radio-and chemotherapy, their invasive …

Exploring multivalency-driven sensitivity modulation for optimization and fine-tuning of avidity-based biosensors

J Bae, Y Ryu, J Choi, MS Jeong, CK Lee… - Biosensors and …, 2025 - Elsevier
The development of multivalent nanoprobes has garnered considerable interest due to their
enhanced sensitivity and precision in diagnosing and monitoring diverse diseases. Despite …