Role of ACTN4 in tumorigenesis, metastasis, and EMT
The actin-binding protein ACTN4 belongs to a family of actin-binding proteins and is a non-
muscle alpha-actinin that has long been associated with cancer development. Numerous …
muscle alpha-actinin that has long been associated with cancer development. Numerous …
Role of ARP2/3 complex-driven actin polymerization in RSV infection
A Paluck, J Osan, L Hollingsworth, SN Talukdar… - Pathogens, 2021 - mdpi.com
Respiratory syncytial virus (RSV) is the leading viral agent causing bronchiolitis and
pneumonia in children under five years old worldwide. The RSV infection cycle starts with …
pneumonia in children under five years old worldwide. The RSV infection cycle starts with …
Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication
W Luo, J Zhang, L Liang, G Wang, Q Li, P Zhu… - PLoS …, 2018 - journals.plos.org
Transcription and replication of the influenza A virus (IAV) genome occur in the nucleus of
infected cells and are carried out by the viral ribonucleoprotein complex (vRNP). As a major …
infected cells and are carried out by the viral ribonucleoprotein complex (vRNP). As a major …
Phosphorylation at the homotypic interface regulates nucleoprotein oligomerization and assembly of the influenza virus replication machinery
Negative-sense RNA viruses assemble large ribonucleoprotein (RNP) complexes that direct
replication and transcription of the viral genome. Influenza virus RNPs contain the …
replication and transcription of the viral genome. Influenza virus RNPs contain the …
MicroRNA profiling of human primary macrophages exposed to dengue virus identifies miRNA-3614-5p as antiviral and regulator of ADAR1 expression
M Diosa-Toro, L Echavarría-Consuegra… - PLoS neglected …, 2017 - journals.plos.org
Background Due to the high burden of dengue disease worldwide, a better understanding of
the interactions between dengue virus (DENV) and its human host cells is of the utmost …
the interactions between dengue virus (DENV) and its human host cells is of the utmost …
Characterization of ACTN4 as a novel antiviral target against SARS-CoV-2
M Zhu, F Huang, H Sun, K Liu, Z Chen, B Yu… - … and Targeted Therapy, 2024 - nature.com
The various mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
pose a substantial challenge in mitigating the viral infectivity. The identification of novel host …
pose a substantial challenge in mitigating the viral infectivity. The identification of novel host …
Human Heat shock protein 40 (Hsp40/DnaJB1) promotes influenza A virus replication by assisting nuclear import of viral ribonucleoproteins
J Batra, S Tripathi, A Kumar, JM Katz, NJ Cox, RB Lal… - Scientific reports, 2016 - nature.com
A unique feature of influenza A virus (IAV) life cycle is replication of the viral genome in the
host cell nucleus. The nuclear import of IAV genome is an indispensable step in establishing …
host cell nucleus. The nuclear import of IAV genome is an indispensable step in establishing …
The nucleoprotein of influenza A virus induces p53 signaling and apoptosis via attenuation of host ubiquitin ligase RNF43
The interplay between influenza virus and host factors to support the viral life cycle is well
documented. Influenza A virus (IAV) proteins interact with an array of cellular proteins and …
documented. Influenza A virus (IAV) proteins interact with an array of cellular proteins and …
[HTML][HTML] Prediction of repurposed drugs for treating lung injury in COVID-19
Background: Coronavirus disease (COVID-19) is an infectious disease discovered in 2019
and currently in outbreak across the world. Lung injury with severe respiratory failure is the …
and currently in outbreak across the world. Lung injury with severe respiratory failure is the …
Influenza A Virus-induced expression of ISG20 inhibits viral replication by interacting with nucleoprotein
H Qu, J Li, L Yang, L Sun, W Liu, H He - Virus genes, 2016 - Springer
Influenza A virus (IAV) is an important pathogen that has a wide range of hosts and
represents a threat to the health of humans and several animal species. IAV infection can …
represents a threat to the health of humans and several animal species. IAV infection can …