Colorectal cancer (CRC) risk is predominantly driven by environmental factors, in particular
diet. A high intake of dietary fat has been implicated as a risk factor inducing the formation of …

A high-fat diet (HFD) induces changes in gut microbiota leading to activation of pro-
inflammatory pathways, and obesity, as a consequence of overnutrition, exacerbates …

Background: Increasingly, studies have discovered that different fatty acids (Fas) are linked
to colorectal cancer (CRC) risk. Methods: We systematically searched Embase and Medline …

Background: Concerns are emerging that a high-fat diet rich in n-6 PUFA (n-6HFD) may alter
gut microbiome and increase the risk of intestinal disorders. Research is needed to model …

Inflammatory bowel diseases (IBD) are chronic inflammatory disorders of the gastrointestinal
tract that encompass two main phenotypes, namely Crohn's disease and ulcerative colitis …

The lungs and large intestine can co-regulate inflammation and immunity through the lung–
gut axis, in which the transportation of the gut microbiota and metabolites is the most …

Lipids are crucial for human health and reproduction and include diverse fatty acids (FAs),
notably polyunsaturated FAs (PUFAs) and short-chain FAs (SCFAs) that are known for their …

Sepsis is extremely heterogeneous pathology characterized by complex metabolic changes.
Fibroblast growth factor 19 (FGF19) is a well‐known intestine‐derived inhibitor of bile acid …

Abundant evidence from in-vitro as well as in-vivo studies supports the gut microbiota-
derived metabolites as crucial executors of diet effect on the host physiology. As such, a …

This review focuses on the role of oxidized sterols in three major gastrointestinal cancers
(hepatocellular carcinoma, pancreatic, and colon cancer) and how the circadian clock …