Biophysical signals act as potent regulators of stem cell function, lineage commitment, and
epigenetic status. In recent years, synthetic biomaterials have been used to study a wide …

Traditional two-dimensional (2D) cell culture systems have contributed tremendously to our
understanding of cancer biology but have significant limitations in mimicking in vivo …

It is critical that epiblast cells within blastocyst-stage embryos receive the necessary
regulatory cues to remain pluripotent until the appropriate time when they are stimulated to …

The field of regenerative engineering relies primarily on the dual technical platforms of cell
selection/conditioning and biomaterial fabrication to support directed cell differentiation. As …

Methods to parse paracrine epithelial-stromal communication networks are a vital need in
drug development, as disruption of these networks underlies diseases ranging from cancer …

Hydrogels have emerged as promising scaffolds in regenerative medicine for the delivery of
biomolecules to promote healing. However, increasing evidence suggests that the context …

The vast potential of human induced pluripotent stem-cell-derived cardiomyocytes (hiPSC-
CMs) in preclinical models of cardiac pathologies, precision medicine, and drug screening …

Oxidized alginate hydrogels are appealing alternatives to natural alginate due to their
favourable biodegradability profiles and capacity to self-crosslink with amine containing …

Cardiomyocytes (CMs) generated from human pluripotent stem cells (hPSCs) are immature
in their structure and function, limiting their potential in disease modeling, drug screening …

Purpose of review Human pluripotent stem cells (hPSCs) are anchorage-dependent cells
that can be cultured on a variety of matrices and express integrins and the machinery for …