Background: Interferon-γ–release assays (IGRAs) are alternatives to the tuberculin skin test
(TST). A recent meta-analysis showed that IGRAs have high specificity, even among …

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Abstract Background. Individuals infected with Mycobacterium tuberculosis (Mtb) may
develop symptoms and signs of disease (tuberculosis disease) or may have no clinical …

All members of the Guidelines Group were asked to complete a World Health Organization
(WHO) declaration of interest form and only two declared a conflict of interest. These were …

Background: Until recently, the tuberculin skin test was the only test for detecting latent
tuberculosis (TB) infection, but 2 ex vivo interferon-γ release assays (IGRAs) are now …

A major challenge in tuberculosis control is the diagnosis and treatment of latent
tuberculosis infection. Until recently, there were no alternatives to the tuberculin skin test …

Tuberculosis continues to cause an unacceptably high toll of disease and death among
children worldwide, particularly in the wake of the HIV epidemic. Increased international …

Tuberculosis (TB) is among the top 10 causes of death among children worldwide; however,
children with TB are given low priority in most national health programs and are neglected in …

The HIV epidemic has led to large increases in the frequency of smear-negative pulmonary
tuberculosis, which has poor treatment outcomes and excessive early mortality compared …

Objectives To evaluate the effectiveness of available rapid diagnostic tests to identify
tuberculosis (TB) infection. Data sources Electronic databases were searched from 1975 to …