The solubility dependent bioavailability problem has become a major hurdle in drug
development processes. Drug nanocrystals have been widely accepted by the …

The solubility and bioavailability of pharmaceutical compounds are increased via size
reduction. The conventional size reduction methods have some disadvantages. The …

Reducing the size of pharmaceutical particles is an approved way to enhance solubility and
bioavailability of a drug, leading to a decrease in the drug dose and its side effects. In this …

Nanostructured materials have been attracting increased attention for a wide variety of
applications due to their superior properties compared to their bulk counterparts. Current …

In the case of pharmaceutical substances the particle size is quite important since it can limit
the bioavailability of poorly soluble drugs. As an example we can refer to the data obtained …

Numerous results of multitude investigations indicate that the particular properties of
supercritical fluids can be conveniently exploited for the formation of submicron particles. In …

Crystalline structure of phytosterols leads to poor bioavailability and makes their
incorporation into foods challenging. Bioaccessibility of first-of-their-kind low-crystallinity …

A large number of pharmaceutical compounds are orally administered to the human body. If
the drug shows a poor water-solubility and therewith low dissolution rate, a high dosage is …

The rapid expansion of a supercritical solution (RESS) process was used to produce
submicron Paracetamol (= Acetaminophen), Mefenamic acid, Nabumetone and Tolbutamide …

The application of supercritical fluids in particle formation processes has attracted great
attention due to numerous advantages over classical size reduction technologies. These …