The emergence and spread of antibiotic resistance is one of the biggest challenges in public
health. There is an urgent need to discover novel agents against the occurrence of multidrug …

Melittin, the main venom component of the European Honeybee, is a cationic linear peptide-
amide of 26 amino acid residues with the sequence: GIGAVLKVLTTGLPALISWIKRKRQQ …

Membrane permeabilizing peptides (MPPs) are as ubiquitous as the lipid bilayer
membranes they act upon. Produced by all forms of life, most membrane permeabilizing …

In spite of great advances in cancer therapy, there is considerable current interest in
developing anticancer agents with a new mode of action because of the development of …

During the last two decades cationic amphiphilic peptides and peptide sequences (CAPs)
with cancer-selective toxicity have appeared. Based on their spectrum of anticancer activity …

Melittin is the principal toxic component in the venom of the European honey bee Apis
mellifera and is a cationic, hemolytic peptide. It is a small linear peptide composed of 26 …

A large variety of antimicrobial peptides have been shown to act, at least in vitro, by poration
of the lipid membrane. The nanometre size of these pores, however, complicates their …

The interaction of antimicrobial peptides (AMPs) with biological membranes is in the focus of
research since several years, and the most important features and modes of action of AMPs …

Cancer treatment by conventional chemotherapy is hindered by toxic side effects and the
frequent development of multi-drug resistance by cancer cells. Cationic antimicrobial …

AR-23 is a melittin-related peptide with 23 residues. Like melittin, its high α-helical
amphipathic structure results in strong bactericidal activity and cytotoxicity. In this study, a …