Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Protein corona formation around nanoparticles–from the past to the future

P Del Pino, B Pelaz, Q Zhang, P Maffre… - Materials …, 2014 - pubs.rsc.org
The protein adsorption layer (aka the “protein corona”) that forms on the surface of colloidal
nanoparticles plays an important role in their interaction with living matter. Thus …

Surface functionalization of nanoparticles with polyethylene glycol: effects on protein adsorption and cellular uptake

B Pelaz, P del Pino, P Maffre, R Hartmann, M Gallego… - ACS …, 2015 - ACS Publications
Here we have investigated the effect of enshrouding polymer-coated nanoparticles (NPs)
with polyethylene glycol (PEG) on the adsorption of proteins and uptake by cultured cells …

Planted Graphene Quantum Dots for Targeted, Enhanced Tumor Imaging and Long‐Term Visualization of Local Pharmacokinetics

H Yan, Q Wang, J Wang, W Shang, Z Xiong… - Advanced …, 2023 - Wiley Online Library
While photoluminescent graphene quantum dots (GQDs) have long been considered very
suitable for bioimaging owing to their protein‐like size, superhigh photostability and in vivo …

A practical guide to single-molecule FRET

R Roy, S Hohng, T Ha - Nature methods, 2008 - nature.com
Single-molecule fluorescence resonance energy transfer (smFRET) is one of the most
general and adaptable single-molecule techniques. Despite the explosive growth in the …

Impact of protein modification on the protein corona on nanoparticles and nanoparticle–cell interactions

L Treuel, S Brandholt, P Maffre, S Wiegele, L Shang… - ACS …, 2014 - ACS Publications
Recent studies have firmly established that cellular uptake of nanoparticles is strongly
affected by the presence and the physicochemical properties of a protein adsorption layer …

Platinum nanoplatforms: classic catalysts claiming a prominent role in cancer therapy

JI Garcia-Peiro, J Bonet-Aleta, J Santamaria… - Chemical Society …, 2022 - pubs.rsc.org
Platinum nanoparticles (Pt NPs) have a well-established role as a classic heterogeneous
catalyst. Also, Pt has traditionally been employed as a component of organometallic drug …

[HTML][HTML] Growth factor delivery using extracellular matrix-mimicking substrates for musculoskeletal tissue engineering and repair

RCH Gresham, CS Bahney, JK Leach - Bioactive Materials, 2021 - Elsevier
Therapeutic approaches for musculoskeletal tissue regeneration commonly employ growth
factors (GFs) to influence neighboring cells and promote migration, proliferation, or …

[HTML][HTML] Nanoparticles for biomedical applications: exploring and exploiting molecular interactions at the nano-bio interface

K Nienhaus, H Wang, GU Nienhaus - Materials Today Advances, 2020 - Elsevier
Nanomaterials have high potential as powerful tools for nanomedicine in a wide range of
most promising applications as highly specific devices for diagnosis and therapy. Yet …

[HTML][HTML] Characterization of protein adsorption onto FePt nanoparticles using dual-focus fluorescence correlation spectroscopy

P Maffre, K Nienhaus, F Amin, WJ Parak… - Beilstein journal of …, 2011 - beilstein-journals.org
Using dual-focus fluorescence correlation spectroscopy, we have analyzed the adsorption of
three human blood serum proteins, namely serum albumin, apolipoprotein AI and …