siRNA-based strategies to combat drug resistance in gastric cancer

AQ Khaleel, MY Alshahrani, JA Rizaev, H Malathi… - Medical Oncology, 2024 - Springer
Chemotherapy is a key treatment option for gastric cancer, but over 50% of patients develop
either inherent or acquired resistance to these drugs, resulting in a 5-year survival rate of …

Stathmin: a protein with many tasks. New biomarker and potential target in cancer

B Belletti, G Baldassarre - Expert opinion on therapeutic targets, 2011 - Taylor & Francis
Introduction: Stathmin is a microtubule-destabilizing phosphoprotein, firstly identified as the
downstream target of many signal transduction pathways. Several studies then indicated …

WTAP facilitates progression of endometrial cancer via CAV‐1/NF‐κB axis

Q Li, C Wang, W Dong, Y Su, Z Ma - Cell biology international, 2021 - Wiley Online Library
Abstract The N6‐methyladenosine (m6A) modification is one of the most prevalent
methylations in eukaryotic messenger RNA (mRNA), and it is essential for the development …

Stathmin1 plays oncogenic role and is a target of microRNA-223 in gastric cancer

W Kang, JHM Tong, AWH Chan, RWM Lung, SL Chau… - Plos one, 2012 - journals.plos.org
Stathmin1 (STMN1) is a candidate oncoprotein and prognosis marker in several kinds of
cancers. This study was aimed to analyze its expression and biological functions in gastric …

Epstein‐Barr virus‐encoded miR‐BART6‐3p inhibits cancer cell proliferation through the LOC553103‐STMN1 axis

D Wang, Z Zeng, S Zhang, F Xiong, B He… - The FASEB …, 2020 - Wiley Online Library
Epstein‐Barr virus (EBV) is a tumorigenic virus that can cause various human malignancies
such as nasopharyngeal carcinoma (NPC) and gastric cancer (GC). EBV encodes 44 …

[HTML][HTML] Overexpression of stathmin 1 is a poor prognostic biomarker in non-small cell lung cancer

W Nie, M Xu, L Gan, H Huang, Q Xiu, B Li - Laboratory investigation, 2015 - Elsevier
Abstract Stathmin 1 (STMN1), a major microtubule-depolymerizing protein, is involved in cell
cycle progression and cell motility. However, the clinical significance of STMN1 expression …

WTAP regulates migration and invasion of cholangiocarcinoma cells

HJ Jo, HE Shim, ME Han, HJ Kim, KS Kim… - Journal of …, 2013 - Springer
Background Wilms' tumor 1-associating protein (WTAP) is a nuclear protein that has been
associated with the regulation of proliferation and apoptosis. Although its dynamic …

High STMN1 level is associated with chemo-resistance and poor prognosis in gastric cancer patients

T Bai, T Yokobori, B Altan, M Ide, E Mochiki… - British journal of …, 2017 - nature.com
Background: Stathmin1 (STMN1) is a cytosolic phosphoprotein that regulates cellular
microtubule dynamics and is known to have oncogenic activity. Despite several reports, its …

Combined proteomics and transcriptomics identifies carboxypeptidase B1 and nuclear factor κB (NF-κB) associated proteins as putative biomarkers of metastasis in …

P Bouchal, M Dvořáková, T Roumeliotis… - Molecular & Cellular …, 2015 - ASBMB
Current prognostic factors are insufficient for precise risk-discrimination in breast cancer
patients with low grade breast tumors, which, in disagreement with theoretical prognosis …

RNAi-mediated stathmin suppression reduces lung metastasis in an orthotopic neuroblastoma mouse model

FL Byrne, L Yang, PA Phillips, LM Hansford, JI Fletcher… - Oncogene, 2014 - nature.com
Metastatic neuroblastoma is an aggressive childhood cancer of neural crest origin. Stathmin,
a microtubule destabilizing protein, is highly expressed in neuroblastoma although its …