The number of adults 65 years and older is increasing worldwide and will represent the 20%
of the population by 2030. Half of them will suffer from obesity. The decline in muscle mass …

Introduction Irisin is a myokine/adipokine induced by the exercise in mice and humans,
which is proposed to induce “browning” of white adipose tissue, its primary target, thus …

It is unclear how physical activity stimulates new bone synthesis. We explored whether irisin,
a newly discovered myokine released upon physical activity, displays anabolic actions on …

Physical exercise is able to improve skeletal health. However, the mechanisms are poorly
known. Irisin, a novel exercise-induced myokine, secreted by skeletal muscle in response to …

Irisin is an exercise-induced myokine expressed as a bioactive peptide in multiple tissues
and organs, and exercise and cold exposure are the major inducers for its secretion. Irisin …

Sedentary life style is considered to be an independent risk factor for many disorders,
including development of type 2 diabetes, obesity, immune dysfunction, asthma, and …

Irisin is a hormone-like molecule mainly released by skeletal muscles in response to
exercise. Irisin induces browning of the white adipose tissue and has been shown to …

Background Osteoporosis is recognized as a skeletal disorder characterized by diminished
bone tissue quality and density. Regular physical exercise is widely acknowledged to …

Irisin is well-known to contribute to bone homeostasis due to its bidirectional regulation on
osteogenesis and osteoclastogenesis. However, the mechanisms of irisin involved in …

Previous results showed that intermittently administered irisin improves bone mass in
normal mice and prevents the development of disuse‐induced osteoporosis and muscular …