Mammalian telomeres are formed by tandem repeats of the TTAGGG sequence, which are
progressively lost with each round of cell division. Telomere protection requires a minimal …

The human papillomavirus (HPV) E7 protein is one of only two viral proteins that remain
expressed in HPV-associated human cancers. HPV E7 proteins share structural and …

In mitotic cells, an error in chromosome segregation occurs when a chromosome is left near
the spindle equator after anaphase onset (lagging chromosome). In PtK1 cells, we found …

Chromosomal instability (CIN) is a defining characteristic of most human cancers. Mutation
of CIN genes increases the probability that whole chromosomes or large fractions of …

Heme oxygenase-1 (HO-1) degrades heme to carbon monoxide (CO), biliverdin, and ferrous
iron. As HO-1 expression is highly increased by stressful conditions, the major role of the …

Purpose: Multiple chromosome abnormalities, including gain of chromosome20q, have
been detected frequently in human pancreatic cancers. Overexpression of the …

Oral white lesions are frequently encountered in daily practice. Most white lesions are
benign (eg, reactive keratoses or keratoses from inflammatory conditions) and the diagnosis …

Aneuploidy is the hallmark of many human cancers. Recent work has strongly suggested
that chromosome missegregation during mitosis is the main cause of aneuploidy and …

Background: The mitotic kinase-encoding gene STK15/BTAK/AuroraA is associated with
aneuploidy and transformation when overexpressed in mammalian cells. STK15 …

Chromosomal instability as manifested by increases in aneuploidy and structural
chromosome aberrations is believed to play a critical role in the intermediate to late stages …