[HTML][HTML] Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles as Natural Nanocarriers in the Treatment of Nephrotoxic Injury In Vitro

MB Convento, AS de Oliveira, MA Boim, FT Borges - Cells, 2024 - mdpi.com
Umbilical cord mesenchymal stem cell-derived extracellular vesicles (UC-EVs) are valuable
in nanomedicine as natural nanocarriers, carrying information molecules from their parent …

Development of an inhibitor of the mutagenic SOS response that suppresses the evolution of quinolone antibiotic resistance

JD Bradbury, T Hodgkinson, AM Thomas… - Chemical …, 2024 - pubs.rsc.org
Antimicrobial resistance (AMR) is a growing threat to health globally, with the potential to
render numerous medical procedures so dangerous as to be impractical. There is therefore …

[HTML][HTML] Evolution of YacG to safeguard DNA gyrase from external perturbation

P Biswas, S Sengupta, V Nagaraja - Research in Microbiology, 2023 - Elsevier
Cells have evolved strategies to safeguard their genome integrity. We describe a
mechanism to counter double strand breaks in the chromosome that involves the protection …

Gallic acid inhibits Staphylococcus aureus RecA protein functions: Role in countering antibiotic resistance in bacteria

K Kiran, KN Patil - Journal of Applied Microbiology, 2024 - academic.oup.com
Aim Recombinase RecA and its homologs play a key role in homologous recombination
DNA repair and revive stalled replication fork DNA synthesis. RecA plays an essential role in …

Mechanisms of Interaction of Escherichia coli Biopolymers with 4-Hexylresorcinol

EV Tereshkin, KB Tereshkina, NG Loiko… - Russian Journal of …, 2023 - Springer
In this study, molecular modeling is used to study the interaction of the autoregulatory factor
of bacteria, a chemical analog of the inducers of anabiosis of 4-hexylresorcinol (4HR), with …

The LexA-RecA* structure reveals a lock-and-key mechanism for SOS activation

MB Cory, A Li, CM Hurley, PJ Carman, RA Pumroy… - bioRxiv, 2023 - biorxiv.org
The bacterial SOS response plays a key role in adaptation to DNA damage, including that
caused by antibiotics. SOS induction begins when activated RecA*, an oligomeric …

Impact of Antibiotics and Biofactor Additives on the Gut Microbiome and Metabolic Pathways in Broiler Chickens

EA Bossila, YA Dowidar, KR Mohamed… - Egyptian Journal of …, 2025 - journals.ekb.eg
Antibiotic use in poultry production raises concerns about microbial resistance and gut
health. This study aims to compare the effects of antibiotic treatment (G1) and Biofactor …

Mutators can increase both the rate of occurrence and specificity of nitrofurantoin resistance mutations

R Kettlewell, JH Forsyth, DR Gifford - bioRxiv, 2024 - biorxiv.org
Antimicrobial resistance is a significant global health crisis, with many antibiotics losing
effectiveness within a decade of their introduction. The antibiotic nitrofurantoin, however …

[HTML][HTML] DinI could be a suitable option in drug targeting strategies to reduce SOS mutagenesis

R Pourahmad Jaktaji, S Mohammadi - Journal of Microbial Biology, 2024 - bjm.ui.ac.ir
Ciprofloxacin induces the SOS response. Induction of the SOS response confers resistance
to ciprofloxacin through activation of DNA polymerase V. However, mutations in lexA …

[PDF][PDF] 4. RecB deficiency in Escherichia coli attenuates DNA Polymerase V localisation and potential mutagenicity in vivo

EK Wright - Targeting Escherichia coli DNA double-strand break …, 2023 - ro.uow.edu.au
There are two major mechanisms that contribute to mutation development in vivo: erroneous
replication and lateral gene transfer1. Erroneous replication can be caused by spontaneous …