Azines, such as pyridines, quinolines, pyrimidines, and pyridazines, are widespread
components of pharmaceuticals. Their occurrence derives from a suite of physiochemical …

Skeletal editing is a straightforward synthetic strategy for precise substitution or
rearrangement of atoms in core ring structures of complex molecules; it enables quick …

Carbon-hydrogen (C− H) functionalization of pyridines is a powerful tool for the rapid
construction and derivatization of many agrochemicals, pharmaceuticals, and materials …

In 2001, our curiosity to understand the stereochemistry of C− H metalation with Pd
prompted our first studies in Pd (II)‐catalyzed asymmetric C− H activation (RSC Research …

Cyclic organic molecules are common among natural products and pharmaceuticals,. In fact,
the overwhelming majority of small-molecule pharmaceuticals contain at least one ring …

Catalytic site-selective functionalization of distal C–H bonds represents a formidable
challenge in organic synthesis. Particularly, the precise functionalization of distal aromatic C …

Pd (II)-catalyzed nondirected C–H functionalization of heteroarenes is a significant
challenge for the following reasons: poor reactivity of electron-deficient heterocycles and the …

Substituted arenes are ubiquitous in molecules with medicinal functions, making their
synthesis a critical consideration when designing synthetic routes. Regioselective C–H …

Direct arene C− H functionalization via nucleophilic aromatic substitution remains a
challenging task. Here we report an iridium nitrenoid-catalysed arene C− H functionalization …

The Catellani reaction, ie, the Pd/norbornene (NBE) catalysis, has been evolved into a
versatile approach to multisubstituted arenes via the ortho-functionalization/ipso-termination …