Inflammation, ictogenesis, and epileptogenesis: An exploration through human disease

THL Tan, P Perucca, TJ O'Brien, P Kwan, M Monif - Epilepsia, 2021 - Wiley Online Library
Epilepsy is seen historically as a disease of aberrant neuronal signaling manifesting as
seizures. With the discovery of numerous auto‐antibodies and the subsequent growth in …

Scenes, spaces, and memory traces: what does the hippocampus do?

EA Maguire, H Intraub, SL Mullally - The Neuroscientist, 2016 - journals.sagepub.com
The hippocampus is one of the most closely scrutinized brain structures in neuroscience.
While traditionally associated with memory and spatial cognition, in more recent years it has …

Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis

SR Irani, AW Michell, B Lang, P Pettingill… - Annals of …, 2011 - Wiley Online Library
Objective: To describe a distinctive seizure semiology that closely associates with voltage‐
gated potassium channel (VGKC)‐complex/Lgi1 antibodies and commonly precedes the …

Immunopathology of autoantibody-associated encephalitides: clues for pathogenesis

CG Bien, A Vincent, MH Barnett, AJ Becker, I Blümcke… - Brain, 2012 - academic.oup.com
Classical paraneoplastic encephalitis syndromes with 'onconeural'antibodies directed to
intracellular antigens, and the recently described paraneoplastic or non-paraneoplastic …

Paraneoplastic encephalomyelopathies: pathology and mechanisms

A McKeon, SJ Pittock - Acta neuropathologica, 2011 - Springer
The last three decades have seen major advances in the understanding of paraneoplastic
and idiopathic autoimmune disorders affecting the central nervous system (CNS). Neural …

Remembering preservation in hippocampal amnesia

IA Clark, EA Maguire - Annual review of psychology, 2016 - annualreviews.org
The lesion-deficit model dominates neuropsychology. This is unsurprising given powerful
demonstrations that focal brain lesions can affect specific aspects of cognition. Nowhere is …

Cytokine dynamics and targeted immunotherapies in autoimmune encephalitis

NL Ciano-Petersen, S Muñiz-Castrillo… - Brain …, 2022 - academic.oup.com
Autoimmune encephalitides constitute a diverse group of immune-mediated central nervous
system disorders mainly characterized by the presence of antibodies targeting neuronal or …

Autoimmune epilepsy

M Toledano, SJ Pittock - Seminars in neurology, 2015 - thieme-connect.com
Seizures are recognized as a common manifestation of autoimmune limbic encephalitis and
multifocal paraneoplastic disorders, but accumulating evidence supports an autoimmune …

An effective immunotherapy regimen for VGKC antibody-positive limbic encephalitis

SH Wong, MD Saunders, AJ Larner, K Das… - Journal of Neurology …, 2010 - jnnp.bmj.com
Background Voltage-gated potassium channel antibody-positive limbic encephalitis (VGKC+
LE) frequently improves with immunotherapy, although the optimum regimen is unknown …

Molecular and cellular mechanisms underlying anti-neuronal antibody mediated disorders of the central nervous system

MH van Coevorden-Hameete, E de Graaff… - Autoimmunity …, 2014 - Elsevier
Over the last decade multiple autoantigens located on the plasma membrane of neurons
have been identified. Neuronal surface antigens include molecules directly involved in …