Various forms of fibrosis, comprising tissue thickening and scarring, are involved in 40% of
deaths across the world. Since the discovery of scarless functional healing in fetuses prior to …

The gastrointestinal tract harbors numerous commensal bacteria, referred to as the
microbiota, that benefit host health by digesting dietary components and eliminating …

Ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family members (ENPP1–7)
have been implicated in key biological and pathophysiological processes, including …

Mast cells and their mediators have been implicated in the pathogenesis of asthma and
allergy for decades. Allergic asthma is a complex chronic lung disease in which several …

Immune-mediated inflammatory diseases (IMIDs) encompass a wide range of seemingly
unrelated conditions, such as multiple sclerosis, rheumatoid arthritis, psoriasis, inflammatory …

Ectonucleotidases are key for purinergic signaling. They control the duration of activity of
purinergic receptor agonists. At the same time, they produce hydrolysis products as …

abstract Basophils have long been neglected in immunological studies because they were
regarded as only minor relatives of mast cells. However, recent advances in analytical tools …

Human basophils, first identified over 140 years ago, account for just 0.5-1% of circulating
leukocytes. While this scarcity long hampered basophil studies, innovations during the past …

It is well known that mast cells (MCs) initiate type I allergic reactions and inflammation in a
quick response to the various stimulants, including—but not limited to—allergens, pathogen …

Until recently, basophils had often been neglected in immunologic studies because of their
minority status among immune cells or confused with tissue-resident mast cells because of …