As a promising alternative platform for cellular immunotherapy, natural killer cells (NK) have
recently gained attention as an important type of innate immune regulatory cell. NK cells can …

Natural killer (NK) cells, the large granular lymphocytes differentiated from the common
lymphoid progenitors, were discovered in early 1970's. They are members of innate …

The mechanisms underlying human natural killer (NK) cell phenotypic and functional
heterogeneity are unknown. Here, we describe the emergence of diverse subsets of human …

Understanding how signals are integrated to control natural killer (NK) cell responsiveness
in the absence of antigen-specific receptors has been a challenge, but recent work has …

Significant progress has been made in recent years toward realizing the potential of natural
killer (NK) cells for cancer immunotherapy. NK cells can respond rapidly to transformed and …

The concept that the immune system can recognize and destroy nascent transformed cells
was originally embodied in the cancer immunosurveillance hypothesis of Burnet and …

The identification of inhibitory NK cell receptors specific for HLA-I molecules (KIRs and
NKG2A) provided the molecular basis for clarifying the mechanism by which NK cells kill …

Natural killer (NK) cells are essential components of the innate immune system and play a
critical role in host immunity against cancer. Recent progress in our understanding of NK cell …

Naive T cells are stimulated by antigen-presenting dendritic cells (DCs) in secondary
lymphoid organs, but whether other types of cell participate in T cell priming is unclear. Here …

Dendritic cells (DCs) present microbial antigens to T cells and provide inflammatory signals
that modulate T cell differentiation. While the role of DCs in adaptive immunity is well …