Born to run: control of transcription elongation by RNA polymerase II
FX Chen, ER Smith, A Shilatifard - Nature reviews Molecular cell …, 2018 - nature.com
The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an
integral part of the implementation of gene expression programmes during development. In …
integral part of the implementation of gene expression programmes during development. In …
MLL-rearranged leukemias—an update on science and clinical approaches
AC Winters, KM Bernt - Frontiers in pediatrics, 2017 - frontiersin.org
The mixed-lineage leukemia 1 (MLL1) gene (now renamed Lysine [K]-specific
MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of …
MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of …
H2B Lys34 ubiquitination induces nucleosome distortion to stimulate Dot1L activity
H Ai, M Sun, A Liu, Z Sun, T Liu, L Cao, L Liang… - Nature Chemical …, 2022 - nature.com
Ubiquitination-dependent histone crosstalk plays critical roles in chromatin-associated
processes and is highly associated with human diseases. Mechanism studies of the …
processes and is highly associated with human diseases. Mechanism studies of the …
Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains
CRISPR-Cas9 genome editing technology holds great promise for discovering therapeutic
targets in cancer and other diseases. Current screening strategies target CRISPR-Cas9 …
targets in cancer and other diseases. Current screening strategies target CRISPR-Cas9 …
Mechanism of cross-talk between H2B ubiquitination and H3 methylation by Dot1L
Methylation of histone H3 K79 by Dot1L is a hallmark of actively transcribed genes that
depends on monoubiquitination of H2B K120 (H2B-Ub) and is an example of histone …
depends on monoubiquitination of H2B K120 (H2B-Ub) and is an example of histone …
BET bromodomain inhibition suppresses the function of hematopoietic transcription factors in acute myeloid leukemia
The bromodomain and extraterminal (BET) protein BRD4 is a validated drug target in
leukemia, yet its regulatory function in this disease is not well understood. Here, we show …
leukemia, yet its regulatory function in this disease is not well understood. Here, we show …
Structural basis of Dot1L stimulation by histone H2B lysine 120 ubiquitination
MI Valencia-Sánchez, P De Ioannes, M Wang… - Molecular cell, 2019 - cell.com
The essential histone H3 lysine 79 methyltransferase Dot1L regulates transcription and
genomic stability and is deregulated in leukemia. The activity of Dot1L is stimulated by mono …
genomic stability and is deregulated in leukemia. The activity of Dot1L is stimulated by mono …
Pharmacological modulation of ubiquitin-proteasome pathways in oncogenic signaling
The ubiquitin-proteasome pathway (UPP) is involved in regulating several biological
functions, including cell cycle control, apoptosis, DNA damage response, and apoptosis. It is …
functions, including cell cycle control, apoptosis, DNA damage response, and apoptosis. It is …
CRISPR–ChIP reveals selective regulation of H3K79me2 by Menin in MLL leukemia
Chromatin regulation involves the selective recruitment of chromatin factors to facilitate DNA
repair, replication and transcription. Here we demonstrate the utility of coupling unbiased …
repair, replication and transcription. Here we demonstrate the utility of coupling unbiased …
Smurfs in protein homeostasis, signaling, and cancer
Protein ubiquitination is an evolutionary conserved highly-orchestrated enzymatic cascade
essential for normal cellular functions and homeostasis maintenance. This pathway relies on …
essential for normal cellular functions and homeostasis maintenance. This pathway relies on …