Spinal pain processing in arthritis: Neuron and glia (inter) actions
HG Schaible, C König… - Journal of …, 2024 - Wiley Online Library
Diseases of joints are among the most frequent causes of chronic pain. In the course of joint
diseases, the peripheral and the central nociceptive system develop persistent …
diseases, the peripheral and the central nociceptive system develop persistent …
Neuromodulation as a potential disease-modifying therapy for osteoarthritis
Abstract Purpose of Review The following review discusses the therapeutic potential of
targeting the autonomic nervous system (ANS) for osteoarthritis (OA) treatment and …
targeting the autonomic nervous system (ANS) for osteoarthritis (OA) treatment and …
Sestrin2 overexpression attenuates osteoarthritis pain via induction of AMPK/PGC-1α-mediated mitochondrial biogenesis and suppression of neuroinflammation
J Sun, FH Song, JY Wu, LQ Zhang, DY Li… - Brain, behavior, and …, 2022 - Elsevier
Background Our previous study indicated that reactive oxygen species (ROS) are critically
involved in chronic pain. Sestrin2 (Sesn2), a novel stress-inducible protein, is evidenced to …
involved in chronic pain. Sestrin2 (Sesn2), a novel stress-inducible protein, is evidenced to …
Pannexin-1 channel inhibition alleviates opioid withdrawal in rodents by modulating locus coeruleus to spinal cord circuitry
Opioid withdrawal is a liability of chronic opioid use and misuse, impacting people who use
prescription or illicit opioids. Hyperactive autonomic output underlies many of the aversive …
prescription or illicit opioids. Hyperactive autonomic output underlies many of the aversive …
Macrophages and glial cells: Innate immune drivers of inflammatory arthritic pain perception from peripheral joints to the central nervous system
KF Malange, JM Navia-Pelaez, EV Dias… - Frontiers in Pain …, 2022 - frontiersin.org
Millions of people suffer from arthritis worldwide, consistently struggling with daily activities
due to debilitating pain evoked by this disease. Perhaps the most intensively investigated …
due to debilitating pain evoked by this disease. Perhaps the most intensively investigated …
Divergent sex-specific pannexin-1 mechanisms in microglia and T cells underlie neuropathic pain
CY Fan, BB McAllister, S Stokes-Heck, EK Harding… - Neuron, 2025 - cell.com
Chronic pain is a leading cause of disability, affecting more women than men. Different
immune cells contribute to this sexual divergence, but the mechanisms, especially in …
immune cells contribute to this sexual divergence, but the mechanisms, especially in …
Neuronal CRMP2 phosphorylation inhibition by the flavonoid, naringenin, contributes to the reversal of spinal sensitization and arthritic pain improvement
YP Jiang, S Wang, WD Lai, XQ Wu, Y Jin, ZH Xu… - Arthritis Research & …, 2022 - Springer
Background Rheumatoid arthritis patients usually suffer from arthritic chronic pain. However,
due to an incomplete understanding of the mechanisms underlying autoimmune disorders …
due to an incomplete understanding of the mechanisms underlying autoimmune disorders …
Sciatic nerve block downregulates the BDNF pathway to alleviate the neonatal incision-induced exaggeration of incisional pain via decreasing microglial activation
X Ding, FF Liao, L Su, X Yang, W Yang, QH Ren… - Brain, Behavior, and …, 2022 - Elsevier
Sciatic nerve block is under investigation as a possible therapeutic strategy for neonatal
injury-induced exaggeration of pain responses to reinjury. Spinal microglial priming, brain …
injury-induced exaggeration of pain responses to reinjury. Spinal microglial priming, brain …
Selective block of sensory neuronal T-type/Cav3. 2 activity mitigates neuropathic pain behavior in a rat model of osteoarthritis pain
B Itson-Zoske, SM Shin, H Xu, C Qiu, F Fan… - Arthritis Research & …, 2022 - Springer
Background Peripheral and central nociceptive sensitization is a critical pathogenetic
component in osteoarthritis (OA) chronic pain. T-type calcium channel 3.2 (CaV3. 2) …
component in osteoarthritis (OA) chronic pain. T-type calcium channel 3.2 (CaV3. 2) …
[HTML][HTML] Analgesic dorsal root ganglion field stimulation blocks both afferent and efferent spontaneous activity in sensory neurons of rats with monosodium iodoacetate …
D Chao, H Tran, QH Hogan, B Pan - Osteoarthritis and cartilage, 2022 - Elsevier
Objectives Chronic joint pain is common in patients with osteoarthritis (OA). Non-steroidal
anti-inflammatory drugs and opioids are used to relieve OA pain, but they are often …
anti-inflammatory drugs and opioids are used to relieve OA pain, but they are often …