IL-17 cytokines are expressed by numerous cells (eg, gamma delta (γδ) T, innate lymphoid
(ILC), Th17, epithelial cells). They contribute to the elimination of bacteria through the …

As a ligand-dependent transcription factor, retinoid-associated orphan receptor γt (RORγt)
that controls T helper (Th) 17 cell differentiation and interleukin (IL)-17 expression plays a …

Asthma is classically described as having either a type 2 (T2) eosinophilic phenotype or a
non-T2 neutrophilic phenotype. T2 asthma usually responds to classical bronchodilation …

Airway remodeling is a frequent pathological feature of severe asthma leading to permanent
airway obstruction in up to 50% of cases and to respiratory disability. Although structural …

Rationale Non-allergic asthma is driven by multiple endotypes of which neutrophilic and
pauci-granulocytic asthma have been best established. However, it is still puzzling what …

Background Clustering approaches using single omics platforms are increasingly used to
characterise molecular phenotypes of eosinophilic and neutrophilic asthma. Effective …

Background: Asthma is a complex disorder with variable clinical expression. Recognizable
clinical and laboratory features define phenotypes, and specific biologic pathways define …

Retinoic acid-related orphan receptor γt (RORγt) regulates immune responses and its
impaired function contributes to inflammatory and autoimmune diseases and may promote …

Asthma is a chronic airway inflammatory disease that affects millions globally. Although
glucocorticoids are a mainstay of asthma treatment, a subset of patients show resistance to …

Zika virus (ZIKV) can be vertically transmitted during pregnancy resulting in a range of
adverse pregnancy outcomes. The decidua is commonly found to be infected by ZIKV, yet …