Therapeutic recombinant protein production in plants: Challenges and opportunities

MJB Burnett, AC Burnett - Plants, People, Planet, 2020 - Wiley Online Library
Societal Impact Statement Therapeutic protein production in plants is an area of great
potential for increasing and improving the production of proteins for the treatment or …

The production of recombinant pharmaceutical proteins in plants

JKC Ma, PMW Drake, P Christou - Nature reviews genetics, 2003 - nature.com
Imagine a world in which any protein, either naturally occurring or designed by man, could
be produced safely, inexpensively and in almost unlimited quantities using only simple …

Molecular farming in plants: host systems and expression technology

RM Twyman, E Stoger, S Schillberg, P Christou… - TRENDS in …, 2003 - cell.com
Plants provide an inexpensive and convenient system for the large-scale production of
valuable recombinant proteins. This principle has been demonstrated by the commercial …

Sowing the seeds of success: pharmaceutical proteins from plants

E Stoger, JKC Ma, R Fischer, P Christou - Current opinion in biotechnology, 2005 - Elsevier
Among the many plant-based production systems that have been developed for
pharmaceutical proteins, seeds have the useful advantage of accumulating proteins in a …

Seed‐based expression systems for plant molecular farming

J Boothe, C Nykiforuk, Y Shen… - Plant Biotechnology …, 2010 - Wiley Online Library
The evolution of the seed system provides enormous adaptability to the gymnosperms and
angiosperms, because of the properties of dormancy, nutrient storage and seedling vigour …

Transgenic plants as protein factories

G Giddings - Current Opinion in Biotechnology, 2001 - Elsevier
Transgenic plants are showing considerable potential for the economic production of
proteins, with a few already being marketed. Recent clinical trials of pharmaceuticals …

Plants as bioreactors for the production of vaccine antigens

S Tiwari, PC Verma, PK Singh, R Tuli - Biotechnology advances, 2009 - Elsevier
Plants have been identified as promising expression systems for commercial production of
vaccine antigens. In phase I clinical trials several plant-derived vaccine antigens have been …

Transgenic plants in the biopharmaceutical market

RM Twyman, S Schillberg, R Fischer - Expert opinion on emerging …, 2005 - Taylor & Francis
Many of our 'small-molecule-drugs' are natural products from plants, or are synthetic
compounds based on molecules found naturally in plants. However, the vast majority of the …

Practical considerations for pharmaceutical antibody production in different crop systems

E Stoger, M Sack, Y Perrin, C Vaquero, E Torres… - Molecular …, 2002 - Springer
The potential of plant cells to produce functional recombinantantibodies has been
demonstrated in a number of different plant systems. Wepresent a comparative study of a …

Plant seeds as bioreactors for recombinant protein production

OS Lau, SSM Sun - Biotechnology advances, 2009 - Elsevier
Plants are attractive expression systems for the economic production of recombinant
proteins. Among the different plant-based systems, plant seed is the leading platform and …