MYC protein interactors in gene transcription and cancer
The transcription factor and oncoprotein MYC is a potent driver of many human cancers and
can regulate numerous biological activities that contribute to tumorigenesis. How a single …
can regulate numerous biological activities that contribute to tumorigenesis. How a single …
How glutamate is managed by the blood–brain barrier
RA Hawkins, JR Viña - Biology, 2016 - mdpi.com
A facilitative transport system exists on the blood–brain barrier (BBB) that has been tacitly
assumed to be a path for glutamate entry to the brain. However, glutamate is a non-essential …
assumed to be a path for glutamate entry to the brain. However, glutamate is a non-essential …
Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code
The serine/threonine protein phosphatase 1 (PP1) dephosphorylates hundreds of key
biological targets by associating with nearly 200 regulatory proteins to form highly specific …
biological targets by associating with nearly 200 regulatory proteins to form highly specific …
Knockout of protein phosphatase 1 in Leishmania major reveals its role during RNA polymerase II transcription termination
The genomes of kinetoplastids are organized into polycistronic transcription units that are
flanked by a modified DNA base (base J, beta-D-glucosyl-hydroxymethyluracil). Previous …
flanked by a modified DNA base (base J, beta-D-glucosyl-hydroxymethyluracil). Previous …
Protein phosphatase 1 is a key player in nuclear events
Reversible protein phosphorylation at serine (Ser), threonine (Thr) and tyrosine (Tyr)
residues is among the major regulatory mechanism in eukaryotic cells. The eukaryotic …
residues is among the major regulatory mechanism in eukaryotic cells. The eukaryotic …
MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability
The c-MYC (MYC) oncoprotein is deregulated in over 50% of cancers, yet regulatory
mechanisms controlling MYC remain unclear. To this end, we interrogated the MYC …
mechanisms controlling MYC remain unclear. To this end, we interrogated the MYC …
How are short exons flanked by long introns defined and committed to splicing?
D Hollander, S Naftelberg, G Lev-Maor, AR Kornblihtt… - Trends in Genetics, 2016 - cell.com
The splice sites (SSs) delimiting an intron are brought together in the earliest step of
spliceosome assembly yet it remains obscure how SS pairing occurs, especially when …
spliceosome assembly yet it remains obscure how SS pairing occurs, especially when …
Identification of a novel base J binding protein complex involved in RNA polymerase II transcription termination in trypanosomes
Base J, β-D-glucosyl-hydroxymethyluracil, is a modification of thymine DNA base involved in
RNA Polymerase (Pol) II transcription termination in kinetoplastid protozoa. Little is …
RNA Polymerase (Pol) II transcription termination in kinetoplastid protozoa. Little is …
Kaposi's sarcoma-associated herpesvirus ORF34 is essential for late gene expression and virus production
M Nishimura, T Watanabe, S Yagi, T Yamanaka… - Scientific Reports, 2017 - nature.com
Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi's
sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. KSHV …
sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. KSHV …
PNUTS/PP1 regulates RNAPII-mediated gene expression and is necessary for developmental growth
A Ciurciu, L Duncalf, V Jonchere, N Lansdale… - PLoS …, 2013 - journals.plos.org
In multicellular organisms, tight regulation of gene expression ensures appropriate tissue
and organismal growth throughout development. Reversible phosphorylation of the RNA …
and organismal growth throughout development. Reversible phosphorylation of the RNA …