Photodynamic therapy (PDT) is a phototoxic treatment with high spatial and temporal control
and has shown tremendous promise in the management of cancer due to its high efficacy …

This review highlights the importance and the complexity of tumour biology and
microenvironment in the progression and therapy resistance of glioma. Specific gene …

Mouse models of human diseases are an essential part of the translational pipeline.
Orthotopic tumour mouse models are increasingly being used in cancer research due to …

Nanoparticle (NP) technology holds significant promise to mediate targeted drug delivery to
specific organs in the body. Understanding the 3D biodistribution of NPs in heterogeneous …

In designing co-clinical cancer studies, preclinical imaging brings unique challenges that
emphasize the gap between man and mouse. Our group is developing quantitative imaging …

Glioblastoma multiforme (GBM) is the most common primary brain tumor, with most patients
dying within 15–18 months of diagnosis despite aggressive therapy. Preclinical GBM …

Background Accurate tumor volume estimation is important for evaluating the response to
radionuclide therapy and external beam radiotherapy as well as to other pharmaceuticals. A …

Quantifying tumor burden is important for following the natural history of orthotopic colon
cancer and therapeutic efficacy. Bioluminescence imaging (BLI) is commonly used for such …

In preclinical studies, accurate monitoring of tumor dynamics is crucial for understanding
cancer biology and evaluating therapeutic interventions. Traditional methods like caliper …

Purpose: Bioluminescent imaging (BLI) is a versatile technique that offers non-invasive and
real-time monitoring of tumor development in preclinical cancer research. However, the …