Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …

Univocal identification of retinal ganglion cells (RGCs) is an essential prerequisite for
studying their degeneration and neuroprotection. Before the advent of phenotypic markers …

Retinal ganglion cell (RGC) death in glaucoma and other optic neuropathies results in
irreversible vision loss due to the mammalian central nervous system's limited regenerative …

Modulating inflammation is critical to enhance nerve regeneration after injury. However,
clinically applicable regenerative therapies that modulate inflammation have not yet been …

Diabetic retinopathy (DR), the most common microvascular compilation of diabetes, is the
leading cause of vision loss and blindness worldwide. Recent studies indicate that retinal …

Previous studies of neuronal survival have primarily focused on identifying intrinsic
mechanisms controlling the process. This study explored how intercellular communication …

Melanopsin signaling within intrinsically photosensitive retinal ganglion cell (ipRGC)
subtypes impacts a broad range of behaviors from circadian photoentrainment to conscious …

Background Neurological dysfunction and glial activation are common in severe infections
such as sepsis. There is a sexual dimorphism in the response to systemic inflammation in …

Tree shrews (TSs) possess a highly developed visual system. Here, we establish an age-
related single-cell RNA sequencing atlas of retina cells from 15 TSs, covering 6 major retina …

Retinal ganglion cells (RGCs), neurons transmitting visual information via the optic nerve,
fail to regenerate their axons after injury. The progressive loss of RGC function underlies the …