Concise review: adipose‐derived stem cells as a novel tool for future regenerative medicine

H Mizuno, M Tobita, AC Uysal - Stem cells, 2012 - academic.oup.com
The potential use of stem cell‐based therapies for the repair and regeneration of various
tissues and organs offers a paradigm shift that may provide alternative therapeutic solutions …

Risk factors in the development of stem cell therapy

CA Herberts, MSG Kwa, HPH Hermsen - Journal of translational medicine, 2011 - Springer
Stem cell therapy holds the promise to treat degenerative diseases, cancer and repair of
damaged tissues for which there are currently no or limited therapeutic options. The …

Safety of intravenous infusion of human adipose tissue-derived mesenchymal stem cells in animals and humans

JC Ra, IS Shin, SH Kim, SK Kang, BC Kang… - Stem cells and …, 2011 - liebertpub.com
Adipose tissue-derived mesenchymal stem cells (AdMSCs) represent an attractive and
ethical cell source for stem cell therapy. With the recent demonstration of MSC homing …

Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease

R Ciccocioppo, ME Bernardo, A Sgarella, R Maccario… - Gut, 2011 - gut.bmj.com
Objective External fistulas represent a disabling manifestation of Crohn's disease with a
difficult curability and a high relapse rate despite a large therapeutic armamentarium. Stem …

Double‐edged sword of mesenchymal stem cells: cancer‐promoting versus therapeutic potential

HY Lee, IS Hong - Cancer science, 2017 - Wiley Online Library
Mesenchymal stem cells (MSCs) derived from adipose tissue, bone marrow, cord blood, and
other tissues, have recently attracted much attention as potential therapeutic agents in …

Risk of tumorigenicity in mesenchymal stromal cell–based therapies—bridging scientific observations and regulatory viewpoints

L Barkholt, E Flory, V Jekerle, S Lucas-Samuel… - Cytotherapy, 2013 - Elsevier
In the past decade, the therapeutic value of mesenchymal stromal cells (MSCs) has been
studied in various indications, thereby taking advantage of their immunosuppressive …

Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn's disease: results from a multicenter phase I/IIa clinical …

F De la Portilla, F Alba, D García-Olmo… - International journal of …, 2013 - Springer
Purpose The management of perianal fistula in patients with Crohn's disease is an
extremely challenging medical problem as many fistulas do not respond to available …

Concise review: dissecting a discrepancy in the literature: do mesenchymal stem cells support or suppress tumor growth?

AH Klopp, A Gupta, E Spaeth, M Andreeff… - Stem cells, 2011 - academic.oup.com
The discovery that mesenchymal stem cells (MSCs) are recruited into tumors has led to a
great deal of interest over the past decade in the function of MSCs in tumors. To address …

Bone marrow mesenchymal stem cells: historical overview and concepts

P Charbord - Human gene therapy, 2010 - liebertpub.com
This review describes the historical emergence of the concept of bone marrow
mesenchymal stem cells (MSCs), summarizing data on Wolf and Trentin's hematopoietic …

Genetic stability of mesenchymal stromal cells for regenerative medicine applications: a fundamental biosafety aspect

S Neri - International journal of molecular sciences, 2019 - mdpi.com
Mesenchymal stem/stromal cells (MSC) show widespread application for a variety of clinical
conditions; therefore, their use necessitates continuous monitoring of their safety. The risk …