A guide to the effects of a large portion of the residues of triosephosphate isomerase on catalysis, stability, druggability, and human disease

V Olivares‐Illana, H Riveros‐Rosas… - Proteins: Structure …, 2017 - Wiley Online Library
Triosephosphate isomerase (TIM) is a ubiquitous enzyme, which appeared early in
evolution. TIM is responsible for obtaining net ATP from glycolysis and producing an extra …

The role of quaternary structure in (β/α) 8-barrel proteins: evolutionary happenstance or a higher level of structure-function relationships?

SRA Devenish, JA Gerrard - Organic & Biomolecular Chemistry, 2009 - pubs.rsc.org
Despite significant effort, the role played by quaternary structure in enzymes often remains
poorly understood. The (β/α) 8-barrel fold is a versatile scaffold that has been employed in a …

On the molecular and cellular effects of omeprazole to further support its effectiveness as an antigiardial drug

G López-Velázquez, C Fernández-Lainez… - Scientific reports, 2019 - nature.com
Research on Giardia lamblia has accumulated large information about its molecular cell
biology and infection biology. However, giardiasis is still one of the commonest parasitic …

High-resolution crystal structure and redox properties of chloroplastic triosephosphate isomerase from Chlamydomonas reinhardtii

M Zaffagnini, L Michelet, C Sciabolini, N Di Giacinto… - Molecular Plant, 2014 - cell.com
Triosephosphate isomerase (TPI) catalyzes the interconversion of glyceraldehyde-3-
phosphate to dihydroxyacetone phosphate. Photosynthetic organisms generally contain two …

Hexameric oligomerization of mitochondrial peroxiredoxin PrxIIF and formation of an ultrahigh affinity complex with its electron donor thioredoxin Trx-o

S Barranco-Medina, T Krell… - Journal of …, 2008 - academic.oup.com
Mitochondria from plants, yeast, and animals each contain at least one peroxiredoxin (Prx)
that is involved in peroxide detoxification and redox signalling. The supramolecular …

[HTML][HTML] Disulfiram as a novel inactivator of Giardia lamblia triosephosphate isomerase with antigiardial potential

A Castillo-Villanueva, Y Rufino-González… - International Journal for …, 2017 - Elsevier
Giardiasis, the infestation of the intestinal tract by Giardia lamblia, is one of the most
prevalent parasitosis worldwide. Even though effective therapies exist for it, the problems …

Determining the molecular mechanism of inactivation by chemical modification of triosephosphate isomerase from the human parasite Giardia lamblia: A study for …

S Enríquez‐Flores… - Proteins: Structure …, 2011 - Wiley Online Library
Giardiasis, the most prevalent intestinal parasitosis in humans, is caused by Giardia lamblia.
Current drug therapies have adverse effects on the host, and resistant strains against these …

Giardial triosephosphate isomerase as possible target of the cytotoxic effect of omeprazole in Giardia lamblia

H Reyes-Vivas, I de la Mora-de la Mora… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Giardiasis is highly prevalent in the developing world, and treatment failures with the
standard drugs are common. This work deals with the proposal of omeprazole as a novel …

Comparison of cysteine content in whole proteomes across the three domains of life

A Castillo-Villanueva, H Reyes-Vivas… - Plos one, 2023 - journals.plos.org
An empirical observation suggests that Giardia lamblia proteins have larger cysteine content
than their counterparts in other organisms. As this parasite lacks conventional antioxidant …

Activity of Thioallyl Compounds From Garlic Against Giardia duodenalis Trophozoites and in Experimental Giardiasis

R Argüello-García, M De la Vega-Arnaud… - Frontiers in Cellular …, 2018 - frontiersin.org
Fresh aqueous extracts (AGEs) and several thioallyl compounds (TACs) from garlic have an
important antimicrobial activity that likely involves their interaction with exposed thiol groups …