Context: Computational modeling involves the use of computer simulations and models to
study and understand real-world phenomena. Its application is particularly relevant in the …

Tumor heterogeneity plays a critical role in tumor development and response to treatment. In
small-cell lung cancer (SCLC), intratumoral heterogeneity is driven in part by the Notch …

Hybrid epithelial/mesenchymal cells (E/M) are key players in aggressive cancer metastasis.
It remains a challenge to understand how these cell states, which are mostly non-existent in …

Introduction Breast tumors often display an astonishing degree of spatial and temporal
heterogeneity, which are associated with cancer progression, drug resistance, and relapse …

Collective cancer invasion exhibits a hierarchical structure characterized by leader-follower
organization. Dynamic gene expression analysis of invading cells using nanobiosensors …

Double-stranded (ds) biosensors are homogeneous oligonucleotide probes for detection of
nucleic acid sequences in biochemical assays and live cell imaging. Locked nucleic acid …

The Notch pathway, an example of juxtacrine signaling, is an evolutionary conserved cell–
cell communication mechanism. It governs emergent spatiotemporal patterning in tissues …

Background Lung cancer is often diagnosed as stage IV metastatic disease and is the
leading cause of cancer-related death worldwide. Expression of micro-ribonucleic acids …

Hepatocellular carcinoma (HCC) is the most common form of liver cancer and remains the
fourth most lethal cancer worldwide. A novel druggable target is urgently needed to …

In 1665, Robert Hooke published his revolutionary book Micrographia [1], where he wrote
about his observation of box-shaped structures under a microscope. It was for the first time …