Phosphoribosyl diphosphate (PRPP) is an important intermediate in cellular metabolism.
PRPP is synthesized by PRPP synthase, as follows: ribose 5-phosphate+ ATP→ PRPP+ …

O-linked β-N-acetyl glucosamine (O-GlcNAc) is at the crossroads of cellular metabolism,
including glucose and glutamine; its dysregulation leads to molecular and pathological …

Nicotinamide mononucleotide (NMN) presents significant therapeutic potential against
aging-related conditions, such as Alzheimer's disease, due to its consistent and strong …

The universally conserved enzyme phosphoribosyl pyrophosphate synthetase (PRPS)
assembles filaments in evolutionarily diverse organisms. PRPS is a key regulator of …

Nicotinamide mononucleotide (NMN) subsists in all living organisms and has drawn
tremendous attention as a nutraceutical and pharmaceutical product for several diseases …

Nicotinamide mononucleotide (NMN), a precursor of NAD+, can be synthesized by the
conversion of nicotinamide with the help of nicotinamide phosphoribosyl transferase …

Phosphoribosyl pyrophosphate (PRPP) is a key intermediate in the biosynthesis of purine
and pyrimidine nucleotides, histidine, tryptophan, and cofactors NAD and NADP. Abnormal …

Tumors override energy stress to grow. However, how nucleotide synthesis is regulated
under energy stress is unclear. We demonstrate here that glucose deprivation or hypoxia …

Phosphoribosyl pyrophosphate synthetase (PRS EC 2.7. 6.1) is a rate-limiting enzyme that
irreversibly catalyzes the formation of phosphoribosyl pyrophosphate (PRPP) from ribose-5 …

Nicotinamide mononucleotide (NMN), one of the crucial precursors of nicotinamide adenine
dinucleotide, has garnered considerable interest for its pharmacological and anti-aging …