Abstract The 1, 2, 3-triazole ring is a major pharmacophore system among nitrogen-
containing heterocycles. These five-membered heterocyclic motifs with three nitrogen …

The rapid proliferation of cancer cells combined with deficient vessels cause regions of
nutrient and O2 deprivation in solid tumors. Some cancer cells can adapt to these extreme …

Positron emission tomography (PET) and fluorescent imaging play a pivotal role in medical
diagnosis, biomedical oncologic research, and drug development process, which include …

The development of heterocyclic derivatives has progressed considerably over the past
decades, and many new carbonic anhydrase inhibitors (CAIs) fall into this field. In particular …

Carbonic anhydrase IX (CAIX) is a tumor-specific and hypoxia-induced biomarker for the
molecular imaging of solid malignancies. The nuclear-and optical-imaging of CAIX …

Physiological hypoxic conditions in the tumor microenvironment and consequential
overexpression of carbonic anhydrase IX (CA IX) are two characteristics shared by …

The tumour-associated, cell membrane-bound isoforms IX and XII of human carbonic
anhydrase (CA, EC 4.2. 1.1) are overexpressed in cancer cells contributing to the hypoxic …

Tumor imaging and delivery of therapeutic agents may be achieved by designing high-
affinity and high-selectivity compounds recognizing a tumor cell-expressing biomarker, such …

Tumor imaging and fluorescence-guided surgical resection offers a promising therapeutic
approach for the treatment of cancer with simple operation. Hypoxia, as a crucial feature in …

Carbonic anhydrases (CAs) are a family of enzymes that play an important pH regulatory
role in health and disease. While different CA isozymes have a high degree of structural …