Supersaturation is a promising strategy to improve gastrointestinal absorption of poorly
water-soluble drugs. Supersaturation is a metastable state and therefore dissolved drugs …

As a subclass of the biopharmaceutical classification system (BCS) class II, basic drugs
(BCS IIB) exhibit pH-dependent solubility and tend to generate supersaturation in the …

Over the past decade, formulation predictive dissolution (fPD) testing has gained increasing
attention. Another mindset is pushed forward where scientists in our field are more confident …

The application of in silico modeling to predict the in vivo outcome of an oral drug product is
gaining a lot of interest. Fully relying on these models as a surrogate tool requires …

This work reports the first cocrystal of the basic drug posaconazole (PSZ). PSZ is poorly
water-soluble and has low and erratic bioavailability based on its large positive food effect …

Abstract Posaconazole (PSZ), an anti-fungal drug, has broad-spectrum activity. But its action
is limited due to the poor solubility of posaconazole. The objective of the present study was …

Purpose Venetoclax, a targeted anticancer agent approved for the treatment of chronic
lymphocytic leukemia and acute myeloid leukemia, is a substrate of cytochrome P450 (CYP) …

Many strategies have been employed to improve oral drug delivery. One such approach
involves the use of supersaturable delivery systems such as amorphous self-micellizing …

The majority of new drug entities exhibits poor water solubility and therefore enabling
formulations are often needed to ensure sufficient in vivo bioavailability upon oral …

The aim of this research was to develop an in silico modeling and simulation approach to
predict the oral performance of a poorly soluble drug candidate, T2CP, formulated as an …